Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption.

• The interdigestive motor rhythm, the migrating motor complex (MMC), is accompanied by active secretion of chloride during periods of distally propagating maximal motor activity (MMC phase III). We studied the behaviour of this system in bile acid malabsorption (BAM), a relative common cause of chronic diarrhoea. We measured motor activity and transmucosal potential difference (PD, reflecting active chloride secretion), in the proximal jejunum in healthy controls (n = 18) and in a group of patients with BAM (n = 11). The phase III-generated voltage was related to the degree of BAM quantified by the (75)SeHCAT test.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Keyword

Adult

Aged

Bile Acids and Salts

metabolism

Case-Control Studies

Chlorides

metabolism

Chronic Disease

Diarrhea

etiology

metabolism

physiopathology

Enteric Nervous System

physiopathology

Female

Gastrointestinal Motility

physiology

Humans

Intestinal Absorption

physiology

Jejunum

metabolism

Malabsorption Syndromes

complications

metabolism

physiopathology

Male

Mechanoreceptors

physiology

Membrane Potentials

physiology

Middle Aged

Myoelectric Complex

Migrating

physiology

Reference Values

Statistics

Nonparametric

Young Adult

Publication and Content Type

ref (subject category)

art (subject category)