Morphogenesis of the thyroid gland.

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Fagman, Henrik,1975 (author)

Morphogenesis of the thyroid gland.

Article/chapterEnglish2010

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Elsevier BV,2010

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LIBRIS-ID:oai:gup.ub.gu.se/133892
https://gup.ub.gu.se/publication/133892URI
https://doi.org/10.1016/j.mce.2009.12.008DOI

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Language:English

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Subject category:for swepub-publicationtype

Notes

Congenital hypothyroidism is mainly due to structural defects of the thyroid gland, collectively known as thyroid dysgenesis. The two most prevalent forms of this condition are abnormal localization of differentiated thyroid tissue (thyroid ectopia) and total absence of the gland (athyreosis). The clinical picture of thyroid dysgenesis suggests that impaired specification, proliferation and survival of thyroid precursor cells and loss of concerted movement of these cells in a distinct spatiotemporal pattern are major causes of malformation. In normal development the thyroid primordium is first distinguished as a thickening of the anterior foregut endoderm at the base of the prospective tongue. Subsequently, this group of progenitors detaches from the endoderm, moves caudally and ultimately differentiates into hormone-producing units, the thyroid follicles, at a distant location from the site of specification. In higher vertebrates later stages of thyroid morphogenesis are characterized by shape remodeling into a bilobed organ and the integration of a second type of progenitors derived from the caudal-most pharyngeal pouches that will differentiate into C-cells. The present knowledge of thyroid developmental dynamics has emerged from embryonic studies mainly in chicken, mouse and more recently also in zebrafish. This review will highlight the key morphogenetic steps of thyroid organogenesis and pinpoint which crucial regulatory mechanisms are yet to be uncovered. Considering the co-incidence of thyroid dysgenesis and congenital heart malformations the possible interactions between thyroid and cardiovascular development will also be discussed.

Subject headings and genre

NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
NATURVETENSKAP Biologi Utvecklingsbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Developmental Biology hsv//eng
Animals
Bone Morphogenetic Proteins
genetics
physiology
Chick Embryo
Congenital Hypothyroidism
physiopathology
Fibroblast Growth Factors
genetics
physiology
Gene Expression Regulation
Developmental
physiology
Heart Defects
Congenital
physiopathology
Humans
Mice
Morphogenesis
genetics
physiology
Neural Crest
abnormalities
growth & development
Organ Size
genetics
physiology
Thyroid Dysgenesis
genetics
physiopathology
Thyroid Gland
abnormalities
embryology
Transcription Factors
genetics
physiology
Zebrafish

Added entries (persons, corporate bodies, meetings, titles ...)

Nilsson, Mikael,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xnimik (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi (creator_code:org_t)

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In:Molecular and cellular endocrinology: Elsevier BV323:1, s. 35-541872-80570303-7207

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