GH dosing guided by individual responsiveness decreases variability in growth response and insulin in GHD and ISS children

• GH responsiveness on growth can be estimated before treatment by use of prediction models in GHD and ISS children, and may be used for individualizing the GH dose to reach a set goal for catch-up growth, i.e. Midparental Height (MPH) SDS. Conclusions: The prospective randomized study shows that by using the GH responsiveness estimated by our prediction model for individualizing the GH dose during 2 years of catch-up growth, too low and too high growth response can be avoided, and the variance in fasting insulin and HOMA was reduced.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

growth hormone

prediction model

individual dosing

Publikations- och innehållstyp

vet (ämneskategori)

kon (ämneskategori)