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A sequence variant ...
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
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Kiemeney, Lambertus A (author)
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Sulem, Patrick (author)
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Besenbacher, Soren (author)
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show more...
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Vermeulen, Sita H (author)
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Sigurdsson, Asgeir (author)
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Thorleifsson, Gudmar (author)
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Gudbjartsson, Daniel F (author)
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Stacey, Simon N (author)
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Gudmundsson, Julius (author)
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Zanon, Carlo (author)
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Kostic, Jelena (author)
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Masson, Gisli (author)
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Bjarnason, Hjordis (author)
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Palsson, Stefan T (author)
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Skarphedinsson, Oskar B (author)
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Gudjonsson, Sigurjon A (author)
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Witjes, J Alfred (author)
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Grotenhuis, Anne J (author)
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Verhaegh, Gerald W (author)
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Bishop, D Timothy (author)
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Sak, Sei Chung (author)
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Choudhury, Ananya (author)
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Elliott, Faye (author)
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Barrett, Jennifer H (author)
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Hurst, Carolyn D (author)
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- de Verdier, Petra J (author)
- Karolinska Institutet
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- Ryk, Charlotta (author)
- Karolinska Institutet
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Rudnai, Peter (author)
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Gurzau, Eugene (author)
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Koppova, Kvetoslava (author)
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Vineis, Paolo (author)
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Polidoro, Silvia (author)
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Guarrera, Simonetta (author)
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Sacerdote, Carlotta (author)
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Campagna, Marcello (author)
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Placidi, Donatella (author)
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Arici, Cecilia (author)
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Zeegers, Maurice P (author)
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Kellen, Eliane (author)
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Gutierrez, Berta Saez (author)
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Sanz-Velez, José I (author)
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Sanchez-Zalabardo, Manuel (author)
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Valdivia, Gabriel (author)
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Garcia-Prats, Maria D (author)
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Hengstler, Jan G (author)
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Blaszkewicz, Meinolf (author)
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Dietrich, Holger (author)
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Ophoff, Roel A (author)
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van den Berg, Leonard H (author)
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Alexiusdottir, Kristin (author)
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Kristjansson, Kristleifur (author)
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- Geirsson, Gudmundur (author)
- Karolinska Institutet
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Nikulasson, Sigfus (author)
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Petursdottir, Vigdis (author)
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Kong, Augustine (author)
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Thorgeirsson, Thorgeir (author)
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Mungan, N Aydin (author)
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- Lindblom, Annika (author)
- Karolinska Institutet
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van Es, Michael A (author)
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Porru, Stefano (author)
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Buntinx, Frank (author)
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Golka, Klaus (author)
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Mayordomo, José I (author)
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Kumar, Rajiv (author)
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Matullo, Giuseppe (author)
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- Steineck, Gunnar, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Kiltie, Anne E (author)
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Aben, Katja K H (author)
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Jonsson, Eirikur (author)
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Thorsteinsdottir, Unnur (author)
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Knowles, Margaret A (author)
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Rafnar, Thorunn (author)
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Stefansson, Kari (author)
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(creator_code:org_t)
- 2010-03-28
- 2010
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:5, s. 415-9
- Related links:
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Abstract
Subject headings
Close
- Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set and tested the top 20 markers from the combined analysis in several European case-control sample sets, with a total of 4,739 cases and 45,549 controls. The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC. Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low-grade stage Ta tumors. The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Alleles
- Chromosomes
- Human
- Pair 4
- Disease-Free Survival
- Europe
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans
- Male
- Models
- Genetic
- Mutation
- Receptor
- Fibroblast Growth Factor
- Type 3
- genetics
- Recurrence
- Risk
- Smoking
- Urinary Bladder Neoplasms
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kiemeney, Lamber ...
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Sulem, Patrick
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Besenbacher, Sor ...
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Vermeulen, Sita ...
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Sigurdsson, Asge ...
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Thorleifsson, Gu ...
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show more...
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Gudbjartsson, Da ...
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Stacey, Simon N
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Gudmundsson, Jul ...
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Zanon, Carlo
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Kostic, Jelena
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Masson, Gisli
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Bjarnason, Hjord ...
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Palsson, Stefan ...
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Skarphedinsson, ...
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Gudjonsson, Sigu ...
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Witjes, J Alfred
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Grotenhuis, Anne ...
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Verhaegh, Gerald ...
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Bishop, D Timoth ...
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Sak, Sei Chung
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Choudhury, Anany ...
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Elliott, Faye
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Barrett, Jennife ...
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Hurst, Carolyn D
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de Verdier, Petr ...
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Ryk, Charlotta
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Rudnai, Peter
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Gurzau, Eugene
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Koppova, Kvetosl ...
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Vineis, Paolo
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Polidoro, Silvia
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Guarrera, Simone ...
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Sacerdote, Carlo ...
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Campagna, Marcel ...
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Placidi, Donatel ...
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Arici, Cecilia
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Zeegers, Maurice ...
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Kellen, Eliane
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Gutierrez, Berta ...
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Sanz-Velez, José ...
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Sanchez-Zalabard ...
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Valdivia, Gabrie ...
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Garcia-Prats, Ma ...
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Hengstler, Jan G
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Blaszkewicz, Mei ...
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Dietrich, Holger
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Ophoff, Roel A
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van den Berg, Le ...
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Alexiusdottir, K ...
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Kristjansson, Kr ...
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Geirsson, Gudmun ...
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Nikulasson, Sigf ...
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Petursdottir, Vi ...
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Kong, Augustine
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Thorgeirsson, Th ...
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Mungan, N Aydin
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Lindblom, Annika
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van Es, Michael ...
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Porru, Stefano
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Buntinx, Frank
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Golka, Klaus
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Mayordomo, José ...
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Kumar, Rajiv
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Matullo, Giusepp ...
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Steineck, Gunnar ...
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Kiltie, Anne E
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Aben, Katja K H
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Jonsson, Eirikur
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Thorsteinsdottir ...
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Knowles, Margare ...
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Rafnar, Thorunn
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Stefansson, Kari
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg
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Karolinska Institutet