A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Golka Klaus) > A sequence variant ...

Details
MARC

Kiemeney, Lambertus A (author)

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-03-28
Springer Science and Business Media LLC,2010

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/134597
https://gup.ub.gu.se/publication/134597URI
https://doi.org/10.1038/ng.558DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:120375072URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set and tested the top 20 markers from the combined analysis in several European case-control sample sets, with a total of 4,739 cases and 45,549 controls. The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC. Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low-grade stage Ta tumors. The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Alleles
Chromosomes
Human
Pair 4
Disease-Free Survival
Europe
Female
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Male
Models
Genetic
Mutation
Receptor
Fibroblast Growth Factor
Type 3
genetics
Recurrence
Risk
Smoking
Urinary Bladder Neoplasms
genetics

Added entries (persons, corporate bodies, meetings, titles ...)

Sulem, Patrick (author)
Besenbacher, Soren (author)
Vermeulen, Sita H (author)
Sigurdsson, Asgeir (author)
Thorleifsson, Gudmar (author)
Gudbjartsson, Daniel F (author)
Stacey, Simon N (author)
Gudmundsson, Julius (author)
Zanon, Carlo (author)
Kostic, Jelena (author)
Masson, Gisli (author)
Bjarnason, Hjordis (author)
Palsson, Stefan T (author)
Skarphedinsson, Oskar B (author)
Gudjonsson, Sigurjon A (author)
Witjes, J Alfred (author)
Grotenhuis, Anne J (author)
Verhaegh, Gerald W (author)
Bishop, D Timothy (author)
Sak, Sei Chung (author)
Choudhury, Ananya (author)
Elliott, Faye (author)
Barrett, Jennifer H (author)
Hurst, Carolyn D (author)
de Verdier, Petra JKarolinska Institutet (author)
Ryk, CharlottaKarolinska Institutet (author)
Rudnai, Peter (author)
Gurzau, Eugene (author)
Koppova, Kvetoslava (author)
Vineis, Paolo (author)
Polidoro, Silvia (author)
Guarrera, Simonetta (author)
Sacerdote, Carlotta (author)
Campagna, Marcello (author)
Placidi, Donatella (author)
Arici, Cecilia (author)
Zeegers, Maurice P (author)
Kellen, Eliane (author)
Gutierrez, Berta Saez (author)
Sanz-Velez, José I (author)
Sanchez-Zalabardo, Manuel (author)
Valdivia, Gabriel (author)
Garcia-Prats, Maria D (author)
Hengstler, Jan G (author)
Blaszkewicz, Meinolf (author)
Dietrich, Holger (author)
Ophoff, Roel A (author)
van den Berg, Leonard H (author)
Alexiusdottir, Kristin (author)
Kristjansson, Kristleifur (author)
Geirsson, GudmundurKarolinska Institutet (author)
Nikulasson, Sigfus (author)
Petursdottir, Vigdis (author)
Kong, Augustine (author)
Thorgeirsson, Thorgeir (author)
Mungan, N Aydin (author)
Lindblom, AnnikaKarolinska Institutet (author)
van Es, Michael A (author)
Porru, Stefano (author)
Buntinx, Frank (author)
Golka, Klaus (author)
Mayordomo, José I (author)
Kumar, Rajiv (author)
Matullo, Giuseppe (author)
Steineck, Gunnar,1952Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xstegu (author)
Kiltie, Anne E (author)
Aben, Katja K H (author)
Jonsson, Eirikur (author)
Thorsteinsdottir, Unnur (author)
Knowles, Margaret A (author)
Rafnar, Thorunn (author)
Stefansson, Kari (author)
Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för onkologi (creator_code:org_t)

Related titles

In:Nature genetics: Springer Science and Business Media LLC42:5, s. 415-91546-17181061-4036

Internet link

Find in a library

Nature genetics (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Kiemeney, Lamber ...; Sulem, Patrick; Besenbacher, Sor ...; Vermeulen, Sita ...; Sigurdsson, Asge ...; Thorleifsson, Gu ...; show more...; Gudbjartsson, Da ...; Stacey, Simon N; Gudmundsson, Jul ...; Zanon, Carlo; Kostic, Jelena; Masson, Gisli; Bjarnason, Hjord ...; Palsson, Stefan ...; Skarphedinsson, ...; Gudjonsson, Sigu ...; Witjes, J Alfred; Grotenhuis, Anne ...; Verhaegh, Gerald ...; Bishop, D Timoth ...; Sak, Sei Chung; Choudhury, Anany ...; Elliott, Faye; Barrett, Jennife ...; Hurst, Carolyn D; de Verdier, Petr ...; Ryk, Charlotta; Rudnai, Peter; Gurzau, Eugene; Koppova, Kvetosl ...; Vineis, Paolo; Polidoro, Silvia; Guarrera, Simone ...; Sacerdote, Carlo ...; Campagna, Marcel ...; Placidi, Donatel ...; Arici, Cecilia; Zeegers, Maurice ...; Kellen, Eliane; Gutierrez, Berta ...; Sanz-Velez, José ...; Sanchez-Zalabard ...; Valdivia, Gabrie ...; Garcia-Prats, Ma ...; Hengstler, Jan G; Blaszkewicz, Mei ...; Dietrich, Holger; Ophoff, Roel A; van den Berg, Le ...; Alexiusdottir, K ...; Kristjansson, Kr ...; Geirsson, Gudmun ...; Nikulasson, Sigf ...; Petursdottir, Vi ...; Kong, Augustine; Thorgeirsson, Th ...; Mungan, N Aydin; Lindblom, Annika; van Es, Michael ...; Porru, Stefano; Buntinx, Frank; Golka, Klaus; Mayordomo, José ...; Kumar, Rajiv; Matullo, Giusepp ...; Steineck, Gunnar ...; Kiltie, Anne E; Aben, Katja K H; Jonsson, Eirikur; Thorsteinsdottir ...; Knowles, Margare ...; Rafnar, Thorunn; Stefansson, Kari; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Nature genetics

By the university: University of Gothenburg; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se