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Genetic variation i...
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
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Wu, Xifeng (author)
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Ye, Yuanqing (author)
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Kiemeney, Lambertus A (author)
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show more...
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Sulem, Patrick (author)
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Rafnar, Thorunn (author)
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Matullo, Giuseppe (author)
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Seminara, Daniela (author)
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Yoshida, Teruhiko (author)
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Saeki, Norihisa (author)
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Andrew, Angeline S (author)
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Dinney, Colin P (author)
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Czerniak, Bogdan (author)
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Zhang, Zuo-Feng (author)
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Kiltie, Anne E (author)
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Bishop, D Timothy (author)
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Vineis, Paolo (author)
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Porru, Stefano (author)
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Buntinx, Frank (author)
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Kellen, Eliane (author)
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Zeegers, Maurice P (author)
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Kumar, Rajiv (author)
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Rudnai, Peter (author)
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Gurzau, Eugene (author)
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Koppova, Kvetoslava (author)
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Mayordomo, Jose Ignacio (author)
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Sanchez, Manuel (author)
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Saez, Berta (author)
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- Lindblom, Annika (author)
- Karolinska Institutet
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- de Verdier, Petra (author)
- Karolinska Institutet
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- Steineck, Gunnar, 1952 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Mills, Gordon B (author)
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Schned, Alan (author)
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Guarrera, Simonetta (author)
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Polidoro, Silvia (author)
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Chang, Shen-Chih (author)
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LIN, JIE (author)
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Chang, David W (author)
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Hale, Katherine S (author)
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Majewski, Tadeusz (author)
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Grossman, H Barton (author)
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Thorlacius, Steinunn (author)
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Thorsteinsdottir, Unnur (author)
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Aben, Katja K H (author)
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Witjes, J Alfred (author)
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Stefansson, Kari (author)
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Amos, Christopher I (author)
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Karagas, Margaret R (author)
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Gu, Jian (author)
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(creator_code:org_t)
- 2009-08-02
- 2009
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:9, s. 991-5
- Related links:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated the top SNP in nine European populations. A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. Combining all subjects (6,667 cases, 39,590 controls), the overall P-value was 2.14 x 10(-10) and the allelic odds ratio was 1.15 (95% confidence interval 1.10-1.20). rs2294008 alters the start codon and is predicted to cause truncation of nine amino acids from the N-terminal signal sequence of the primary PSCA translation product. In vitro reporter gene assay showed that the variant allele significantly reduced promoter activity. Resequencing of the PSCA genomic region showed that rs2294008 is the only common missense SNP in PSCA. Our data identify rs2294008 as a new bladder cancer susceptibility locus.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Alleles
- Antigens
- Neoplasm
- genetics
- immunology
- Case-Control Studies
- Chromosome Mapping
- Chromosomes
- Human
- Pair 8
- GPI-Linked Proteins
- Gene Frequency
- Genes
- Reporter
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Haplotypes
- Heterozygote
- Homozygote
- Humans
- Linkage Disequilibrium
- Logistic Models
- Male
- Membrane Glycoproteins
- genetics
- Multivariate Analysis
- Mutation
- Missense
- Neoplasm Proteins
- genetics
- Polymorphism
- Single Nucleotide
- Promoter Regions
- Genetic
- Reproducibility of Results
- Urinary Bladder Neoplasms
- genetics
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Wu, Xifeng
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Ye, Yuanqing
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Kiemeney, Lamber ...
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Sulem, Patrick
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Rafnar, Thorunn
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Matullo, Giusepp ...
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show more...
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Seminara, Daniel ...
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Yoshida, Teruhik ...
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Saeki, Norihisa
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Andrew, Angeline ...
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Dinney, Colin P
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Czerniak, Bogdan
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Zhang, Zuo-Feng
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Kiltie, Anne E
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Bishop, D Timoth ...
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Vineis, Paolo
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Porru, Stefano
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Buntinx, Frank
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Kellen, Eliane
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Zeegers, Maurice ...
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Kumar, Rajiv
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Rudnai, Peter
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Gurzau, Eugene
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Koppova, Kvetosl ...
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Mayordomo, Jose ...
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Sanchez, Manuel
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Saez, Berta
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Lindblom, Annika
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de Verdier, Petr ...
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Steineck, Gunnar ...
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Mills, Gordon B
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Schned, Alan
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Guarrera, Simone ...
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Polidoro, Silvia
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Chang, Shen-Chih
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LIN, JIE
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Chang, David W
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Hale, Katherine ...
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Majewski, Tadeus ...
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Grossman, H Bart ...
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Thorlacius, Stei ...
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Thorsteinsdottir ...
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Aben, Katja K H
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Witjes, J Alfred
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Stefansson, Kari
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Amos, Christophe ...
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Karagas, Margare ...
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Gu, Jian
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg
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Karolinska Institutet