Association of SRD5A2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in Chinese elderly men.

• Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5α reductase type II (SRD5A2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3α,17β-diol-glucuronide (3α-diol-G). However, this association was not consistently found among different ethnic groups. Thus, we aimed to determine whether the association with SRD5A2 genetic variations exists in a cohort of healthy Chinese elderly men, by examining 2 metabolite conjugates: androstane-3α,l7β-diol-3-glucuronide (3α-diol-3G) and androstane-3α,17β-diol-17-glucuronide (3α-diol-17G).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

3-Oxo-5-alpha-Steroid 4-Dehydrogenase

genetics

Aged

Androstane-3

17-diol

analogs & derivatives

blood

Asian Continental Ancestry Group

Chromatography

Gas

Chromatography

Liquid

Dihydrotestosterone

blood

Haplotypes

Hong Kong

Humans

Linkage Disequilibrium

Male

Mass Spectrometry

Membrane Proteins

genetics

Polymorphism

Single Nucleotide

Sex Hormone-Binding Globulin

analysis

Testosterone

blood

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)