Association of SRD5A2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in Chinese elderly men.

Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5α reductase type II (SRD5A2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3α,17β-diol-glucuronide (3α-diol-G). However, this association was not consistently found among different ethnic groups. Thus, we aimed to determine whether the association with SRD5A2 genetic variations exists in a cohort of healthy Chinese elderly men, by examining 2 metabolite conjugates: androstane-3α,l7β-diol-3-glucuronide (3α-diol-3G) and androstane-3α,17β-diol-17-glucuronide (3α-diol-17G).

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
3-Oxo-5-alpha-Steroid 4-Dehydrogenase
genetics
Aged
Androstane-3
17-diol
analogs & derivatives
blood
Asian Continental Ancestry Group
Chromatography
Gas
Chromatography
Liquid
Dihydrotestosterone
blood
Haplotypes
Hong Kong
Humans
Linkage Disequilibrium
Male
Mass Spectrometry
Membrane Proteins
genetics
Polymorphism
Single Nucleotide
Sex Hormone-Binding Globulin
analysis
Testosterone
blood

Tang, Nelson L S (author)
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xohlcl (author)
Eriksson, Anna-Lena,1971Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xeannj (author)
Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xvanli (author)
Liao, ChenDi (author)
Wang, Xingyan (author)
Chan, Frank W K (author)
Kwok, Anthony (author)
Orwoll, Eric (author)
Kwok, Timothy C Y (author)
Woo, Jean (author)
Leung, Ping Chung (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin (creator_code:org_t)

In:Clinical chemistry: Oxford University Press (OUP)56:11, s. 1742-91530-85610009-9147

By the author/editor: Jiang, Jieying; Tang, Nelson L S; Ohlsson, Claes, ...; Eriksson, Anna-L ...; Vandenput, Liesb ...; Liao, ChenDi; show more...; Wang, Xingyan; Chan, Frank W K; Kwok, Anthony; Orwoll, Eric; Kwok, Timothy C ...; Woo, Jean; Leung, Ping Chun ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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