Reversible elevations of serum creatinine levels but no effect on glomerular filtration during treatment with the direct thrombin inhibitor AZD0837.

• Reversible mean increases in serum creatinine (approx. 10%) have been observed during clinical investigations of the oral direct thrombin inhibitor AZD0837. The aim of this study was to evaluate whether the increase in s-creatinine is due to a decrease in renal glomerular filtration rate (GFR) or an inhibition of the tubular secretion of creatinine.

Keyword

Aged

Amidines

pharmacokinetics

pharmacology

Anti-Ulcer Agents

pharmacology

Area Under Curve

Azetidines

pharmacokinetics

pharmacology

Biological Markers

blood

Cimetidine

pharmacology

Creatinine

blood

Cross-Over Studies

Female

Fibrinolytic Agents

pharmacokinetics

pharmacology

Glomerular Filtration Rate

drug effects

Humans

Kidney Function Tests

Kidney Tubules

drug effects

metabolism

Male

Middle Aged

Stroke

etiology

prevention & control

Thrombin

antagonists & inhibitors

Publication and Content Type

ref (subject category)

art (subject category)