Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years.

• Cerebrospinal fluid (CSF) biomarkers and quantitative EEG show particular patterns of change in Alzheimer's disease (AD) and reflect neuropathologic processes and cerebral function, respectively. The changes precede cognitive decline and should be visible already in preclinical stages. We therefore aimed to investigate their relationship in cognitively healthy individuals.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Aged

Amyloid beta-Peptides

cerebrospinal fluid

Apolipoprotein E4

genetics

Biological Markers

cerebrospinal fluid

Brain

physiology

Cognition

physiology

Electroencephalography

Female

Humans

Male

Neuropsychological Tests

Peptide Fragments

cerebrospinal fluid

Phosphorylation

Regression Analysis

Spinal Puncture

Theta Rhythm

Time Factors

tau Proteins

cerebrospinal fluid

metabolism

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)