Sökning: (WFRF:(Fazekas Franz)) pers:(Hennerici Michael) pers:(Waldemar Gunhild)
> (2010) >
Neuropsychological ...
-
Madureira, Sofia
(författare)
Neuropsychological Predictors of Dementia in a Three-Year Follow-Up Period: Data from the LADIS Study
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/139848
-
https://gup.ub.gu.se/publication/139848URI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
BACKGROUND: White matter changes (WMC) are related to cognitive deficits and dementia. Our aim was to determine the extent to which the performance in neuropsychological tests would be able to predict the clinical diagnosis of dementia. METHODS: The LADIS (Leukoaraiosis and Disability) is a prospective study that evaluates the impact of WMC on the transition of independent elderly to disability. The subjects were evaluated at baseline and yearly during 3 years with a comprehensive clinical, functional and neuropsychological protocol. At each visit, dementia was classified according to clinical criteria. The performance in the neuropsychological batteries was compared according to the clinical diagnosis of dementia. RESULTS: From the initially enrolled 639 subjects, 480 were evaluated at year 3. Dementia was diagnosed in 90 participants. The demented subjects had worse performance in almost all the baseline cognitive tests. Using receiver operating characteristic curves, we found that the Vascular Dementia Assessment Scale (VADAS) battery had higher sensitivity and specificity rates (area under the curve = 82%) to identify dementia compared with the Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale. Worse performance on baseline MMSE (beta = 0.33; p < 0.001) and VADAS (beta = -0.07; p = 0.02) were predictors of dementia (regression analyses). CONCLUSION: Performance on the MMSE and the VADAS battery were important predictors of dementia at a 3-year period.
Ämnesord och genrebeteckningar
-
white-matter changes
-
vascular cognitive impairment
-
alzheimers-disease
-
hyperintensities
-
individuals
-
performance
-
disability
-
impact
-
attention
-
deficits
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Verdelho, Ana
(författare)
-
Moleiro, Carla
(författare)
-
Ferro, Jose M.
(författare)
-
Erkinjuntti, Timo
(författare)
-
Jokinen, Hanna
(författare)
-
Pantoni, Leonardo
(författare)
-
Fazekas, Franz
(författare)
-
Van der Flier, Wiesje
(författare)
-
Visser, Marieke
(författare)
-
Waldemar, Gunhild
(författare)
-
Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xwaand
(författare)
-
Hennerici, Michael
(författare)
-
Inzitari, Domenico
(författare)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:DEMENTIA AND GERIATRIC COGNITIVE DISORDERS29:4, s. 325-3341420-8008
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Madureira, Sofia
-
Verdelho, Ana
-
Moleiro, Carla
-
Ferro, Jose M.
-
Erkinjuntti, Tim ...
-
Jokinen, Hanna
-
visa fler...
-
Pantoni, Leonard ...
-
Fazekas, Franz
-
Van der Flier, W ...
-
Visser, Marieke
-
Waldemar, Gunhil ...
-
Wallin, Anders, ...
-
Hennerici, Micha ...
-
Inzitari, Domeni ...
-
visa färre...
- Artiklar i publikationen
-
DEMENTIA AND GER ...
- Av lärosätet
-
Göteborgs universitet