Search: WFRF:(Ohlsson Bertil 1954) >
Copper induces the ...
Copper induces the expression of cholesterogenic genes in human macrophages.
-
- Svensson, Per-Arne, 1969 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
-
- Englund, Mikael C. O., 1971 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
-
- Markström, Emilia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
-
show more...
-
- Ohlsson, Bertil, 1954 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
-
- Jernås, Margareta, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
- Billig, Håkan, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology
-
- Torgerson, Jarl S, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
- Wiklund, Olov, 1943 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
-
- Carlsson, Lena M S, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
- Carlsson, Björn, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
show less...
-
(creator_code:org_t)
- 2003
- 2003
- English.
-
In: Atherosclerosis. - 0021-9150. ; 169:1, s. 71-6
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- Accumulation of lipids and cholesterol by macrophages and subsequent transformation into foam cells are key features in development of atherosclerosis. Serum copper concentrations have been shown to be associated with cardiovascular disease. However, the mechanism behind the proatherogenic effect of copper is not clear. We used DNA microarrays to define the changes in gene expression profile in response to copper exposure of human macrophages. Expression monitoring by DNA microarray revealed 91 genes that were regulated. Copper increased the expression of seven cholesterogenic genes (3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) synthase, IPP isomerase, squalene synthase, squalene epoxidase, methyl sterol oxidase, H105e3 mRNA and sterol-C5-desaturase) and low-density lipoprotein receptor (LDL-R), and decreased the expression of CD36 and lipid binding proteins. The expression of LDL-R and HMG CoA reductase was also investigated using real time PCR. The expression of both of these genes was increased after copper treatment of macrophages (P<0.01 and P<0.01, respectively). We conclude that copper activates cholesterogenic genes in macrophages, which may provide a mechanism for the association between copper and atherosclerosis. The effect of copper on cholesterogenic genes may also have implications for liver steatosis in early stages of Wilson's disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Cholesterol
- genetics
- Copper Sulfate
- pharmacology
- Gene Expression Profiling
- Gene Expression Regulation
- drug effects
- Humans
- Hydroxymethylglutaryl CoA Reductases
- genetics
- metabolism
- Macrophages
- drug effects
- metabolism
- Polymerase Chain Reaction
- Receptors
- LDL
- genetics
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Svensson, Per-Ar ...
-
Englund, Mikael ...
-
Markström, Emili ...
-
Ohlsson, Bertil, ...
-
Jernås, Margaret ...
-
Billig, Håkan, 1 ...
-
show more...
-
Torgerson, Jarl ...
-
Wiklund, Olov, 1 ...
-
Carlsson, Lena M ...
-
Carlsson, Björn, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Physiology
- Articles in the publication
-
Atherosclerosis
- By the university
-
University of Gothenburg