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Comorbidity burden ...
Comorbidity burden in adult atopic dermatitis : a population-based study
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- Thyssen, Jacob P. (författare)
- Department of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol & Venereol, Copenhagen, Denmark.
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- Henrohn, Dan (författare)
- Uppsala universitet,Uppsala University,Dept Inflammat & Immunol, Pfizer AB, Stockholm, Sweden.,Institutionen för medicinska vetenskaper
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- Neary, Maureen P. (författare)
- Department of Inflammation and Immunology, Pfizer Inc., PA, Collegeville, United States,Pfizer Inc, Dept Inflammat & Immunol, Collegeville, PA USA.
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- Geale, Kirk (författare)
- Umeå University,Umeå universitet,Dermatologi och venereologi,Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, Dermatol & Venereol, Umeå, Sweden.
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- Dun, Alexander R. (författare)
- Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.
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- Ortsäter, Gustaf (författare)
- Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.
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- Lindberg, Ingrid (författare)
- Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.
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- De Geer, Anna (författare)
- Department of Inflammation and Immunology, Pfizer AB, Stockholm, Sweden,Dept Inflammat & Immunol, Pfizer AB, Stockholm, Sweden.
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- Neregård, Petra (författare)
- Department of Inflammation and Immunology, Pfizer AB, Stockholm, Sweden,Dept Inflammat & Immunol, Pfizer AB, Stockholm, Sweden.
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- Cha, Amy (författare)
- Department of Inflammation and Immunology, Pfizer Inc., NY, New York, United States,Pfizer Inc, Dept Inflammat & Immunol, New York, NY USA.
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- Cappelleri, Joseph C. (författare)
- Global Biometrics and Data Management (Statistics), Pfizer Inc., CT, Groton, United States,Pfizer Inc, Global Biometr & Data Management Stat, Groton, CT USA.
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- Romero, William (författare)
- Department of Inflammation and Immunology, Pfizer Ltd., Surrey, United Kingdom,Pfizer Limited, UK,Pfizer Ltd, Dept Inflammat & Immunol, Surrey, England.
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- von Kobyletzki, Laura (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Occupat & Environm Dermatol, Lund, Sweden.
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Department of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol & Venereol, Copenhagen, Denmark (creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: JEADV Clinical Practice. - : John Wiley & Sons. - 2768-6566. ; 3:1, s. 128-141
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that has been shown to be associated with allergic comorbidities. However, studies examining comorbidities in patients with AD are incomplete, which may contribute to suboptimal care.Objectives: The objective was to compare the risk of developing different allergic and nonallergic comorbidities among adult patients with AD to that of a matched reference cohort in Sweden.Methods: This was a nationwide population-based cohort study using longitudinal data from primary and specialist care registers. AD patients were identified by confirmed diagnosis in primary or specialist care. A non-AD reference cohort was randomly drawn from the general population and matched 1:1 with the AD patients on age, gender, and geographical region. The risk of developing the following conditions was evaluated: asthma, food hypersensitivity, allergic rhinitis, neurological disorders, psychiatric disorders, infections, immunological & inflammatory disorders, type 1 diabetes (T1D), type 2 diabetes (T2D), endocrine & metabolic disorders, skeletal disorders, ocular disorders, cardiovascular diseases, and malignancies.Results: This study included 107,774 AD patients [mild-to-moderate (n = 92,413) and severe (n = 15,361)] and an equally-sized reference cohort. AD patients displayed a higher risk of developing comorbid conditions for all investigated categories, except for T1D, compared with the reference cohort. The highest risk compared with the reference cohort was observed for allergic comorbidities followed by immunological & inflammatory disorders (hazard ratio: 2.15) and infections (hazard ratio: 2.01). Patients with AD also had higher risk of developing multiple comorbidities (2 or more). The risk of comorbidity onset increased alongside AD severity and patients with active AD were associated with increased risk of comorbidity onset compared with patients in remission.Conclusions: AD patients are at an increased risk of developing many comorbidities that extend beyond allergic conditions. This study highlights the need for interdisciplinary follow-up of comorbidities in the management of AD patients to reduce overall patient burden.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- atopic eczema
- epidemiology
- atopic eczema
- epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Thyssen, Jacob P ...
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Henrohn, Dan
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Neary, Maureen P ...
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Geale, Kirk
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Dun, Alexander R ...
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Ortsäter, Gustaf
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visa fler...
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Lindberg, Ingrid
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De Geer, Anna
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Neregård, Petra
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Cha, Amy
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Cappelleri, Jose ...
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Romero, William
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von Kobyletzki, ...
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