Breast cancer risk after radiation treatment at infancy: potential consequences of radiation-induced genomic instability.

• Swedish hemangioma patients were treated in infancy mainly by external application of radium-226 starting from 1920. This work analysed the radiation risk among 17,158 women with a total of 678 breast cancer incidence cases with models of carcinogenesis and empirical excess relative risk models. Models incorporating effects of genomic instability were developed and applied to the hemangioma cohort. The description of the radiation risk was significantly improved with a model of genomic instability at an early stage of carcinogenesis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adolescent

Adult

Breast Neoplasms

epidemiology

genetics

Child

Child

Preschool

Computer Simulation

Female

Genomic Instability

genetics

Humans

Incidence

Infant

Middle Aged

Models

Genetic

Neoplasms

Radiation-Induced

epidemiology

genetics

Radiotherapy

Conformal

utilization

Risk Assessment

Risk Factors

Sweden

epidemiology

Young Adult

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)