Search: WFRF:(Pekna Marcela 1966) >
Complement opsoniza...
Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell response.
-
Bila, Custodio (author)
-
Oberhauser, Verena (author)
-
Ammann, Christoph G (author)
-
show more...
-
Ejaz, Asim (author)
-
Huber, Georg (author)
-
Schimmer, Simone (author)
-
Messer, Ron (author)
-
- Pekna, Marcela, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
von Laer, Dorothee (author)
-
Dittmer, Ulf (author)
-
Hasenkrug, Kim J (author)
-
Stoiber, Heribert (author)
-
Bánki, Zoltán (author)
-
show less...
-
(creator_code:org_t)
- 2011
- 2011
- English.
-
In: Journal of virology. - 1098-5514. ; 85:2, s. 1151-5
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- B cells are one of the targets of Friend virus (FV) infection, a well-established mouse model often used to study retroviral infections in vivo. Although B cells may be effective in stimulating cytotoxic T lymphocyte responses, studies involving their role in FV infection have mainly focused on neutralizing antibody production. Here we show that polyclonal activation of B cells promotes their infection with FV both in vitro and in vivo. Furthermore, we demonstrate that complement opsonization of Friend murine leukemia virus (F-MuLV) enhances infection of B cells, which correlates with increased potency of B cells to activate FV-specific CD8(+) T cells.
Keyword
- Animals
- B-Lymphocytes
- virology
- CD8-Positive T-Lymphocytes
- immunology
- Cells
- Cultured
- Complement System Proteins
- immunology
- Friend murine leukemia virus
- immunology
- pathogenicity
- Mice
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bila, Custodio
-
Oberhauser, Vere ...
-
Ammann, Christop ...
-
Ejaz, Asim
-
Huber, Georg
-
Schimmer, Simone
-
show more...
-
Messer, Ron
-
Pekna, Marcela, ...
-
von Laer, Doroth ...
-
Dittmer, Ulf
-
Hasenkrug, Kim J
-
Stoiber, Heriber ...
-
Bánki, Zoltán
-
show less...
- Articles in the publication
-
Journal of virol ...
- By the university
-
University of Gothenburg