Search: (WFRF:(Herman Joseph)) pers:(Szatmari Peter)
> (2010) >
A genome-wide scan ...
A genome-wide scan for common alleles affecting risk for autism.
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Anney, Richard (author)
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Klei, Lambertus (author)
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Pinto, Dalila (author)
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show more...
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Regan, Regina (author)
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Conroy, Judith (author)
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Magalhaes, Tiago R (author)
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Correia, Catarina (author)
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Abrahams, Brett S (author)
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Sykes, Nuala (author)
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Pagnamenta, Alistair T (author)
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Almeida, Joana (author)
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Bacchelli, Elena (author)
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Bailey, Anthony J (author)
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Baird, Gillian (author)
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Battaglia, Agatino (author)
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Berney, Tom (author)
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Bolshakova, Nadia (author)
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Bölte, Sven (author)
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Bolton, Patrick F. (author)
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Bourgeron, Thomas (author)
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Brennan, Sean (author)
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Brian, Jessica (author)
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Carson, Andrew R (author)
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Casallo, Guillermo (author)
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Casey, Jillian (author)
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Chu, Su H (author)
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Cochrane, Lynne (author)
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Corsello, Christina (author)
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Crawford, Emily L (author)
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Crossett, Andrew (author)
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Dawson, Geraldine (author)
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de Jonge, Maretha (author)
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Delorme, Richard (author)
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Drmic, Irene (author)
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Duketis, Eftichia (author)
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Duque, Frederico (author)
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Estes, Annette (author)
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Farrar, Penny (author)
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Fernandez, Bridget A (author)
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Folstein, Susan E (author)
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Fombonne, Eric (author)
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Freitag, Christine M (author)
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Gilbert, John (author)
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- Gillberg, Christopher, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Glessner, Joseph T (author)
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Goldberg, Jeremy (author)
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Green, Jonathan (author)
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Guter, Stephen J (author)
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Hakonarson, Hakon (author)
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Heron, Elizabeth A (author)
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Hill, Matthew (author)
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Holt, Richard (author)
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Howe, Jennifer L (author)
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Hughes, Gillian (author)
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Hus, Vanessa (author)
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Igliozzi, Roberta (author)
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Kim, Cecilia (author)
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Klauck, Sabine M (author)
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Kolevzon, Alexander (author)
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Korvatska, Olena (author)
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Kustanovich, Vlad (author)
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Lajonchere, Clara M (author)
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Lamb, Janine A (author)
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Laskawiec, Magdalena (author)
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Leboyer, Marion (author)
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Le Couteur, Ann (author)
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Leventhal, Bennett L (author)
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Lionel, Anath C (author)
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Liu, Xiao-Qing (author)
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Lord, Catherine (author)
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Lotspeich, Linda (author)
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Lund, Sabata C (author)
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Maestrini, Elena (author)
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Mahoney, William (author)
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Mantoulan, Carine (author)
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Marshall, Christian R (author)
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McConachie, Helen (author)
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McDougle, Christopher J (author)
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McGrath, Jane (author)
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McMahon, William M (author)
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Melhem, Nadine M (author)
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Merikangas, Alison (author)
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Migita, Ohsuke (author)
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Minshew, Nancy J (author)
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Mirza, Ghazala K (author)
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Munson, Jeff (author)
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Nelson, Stanley F (author)
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Noakes, Carolyn (author)
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Noor, Abdul (author)
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- Nygren, Gudrun, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Oliveira, Guiomar (author)
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Papanikolaou, Katerina (author)
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Parr, Jeremy R (author)
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Parrini, Barbara (author)
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Paton, Tara (author)
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Pickles, Andrew (author)
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Piven, Joseph (author)
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Posey, David J (author)
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Poustka, Annemarie (author)
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Poustka, Fritz (author)
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Prasad, Aparna (author)
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Ragoussis, Jiannis (author)
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Renshaw, Katy (author)
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Rickaby, Jessica (author)
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Roberts, Wendy (author)
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Roeder, Kathryn (author)
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Roge, Bernadette (author)
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Rutter, Michael L (author)
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Bierut, Laura J (author)
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Rice, John P (author)
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Salt, Jeff (author)
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Sansom, Katherine (author)
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Sato, Daisuke (author)
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Segurado, Ricardo (author)
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Senman, Lili (author)
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Shah, Naisha (author)
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Sheffield, Val C (author)
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Soorya, Latha (author)
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Sousa, Inês (author)
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Stoppioni, Vera (author)
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Strawbridge, Christina (author)
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Tancredi, Raffaella (author)
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Tansey, Katherine (author)
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Thiruvahindrapduram, Bhooma (author)
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Thompson, Ann P (author)
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Thomson, Susanne (author)
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Tryfon, Ana (author)
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Tsiantis, John (author)
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Van Engeland, Herman (author)
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Vincent, John B (author)
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Volkmar, Fred (author)
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Wallace, Simon (author)
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Wang, Kai (author)
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Wang, Zhouzhi (author)
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Wassink, Thomas H (author)
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Wing, Kirsty (author)
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Wittemeyer, Kerstin (author)
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Wood, Shawn (author)
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Yaspan, Brian L (author)
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Zurawiecki, Danielle (author)
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Zwaigenbaum, Lonnie (author)
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Betancur, Catalina (author)
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Buxbaum, Joseph D (author)
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Cantor, Rita M (author)
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Cook, Edwin H (author)
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Coon, Hilary (author)
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Cuccaro, Michael L (author)
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Gallagher, Louise (author)
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Geschwind, Daniel H (author)
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Gill, Michael (author)
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Haines, Jonathan L (author)
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Miller, Judith (author)
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Monaco, Anthony P (author)
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Nurnberger, John I (author)
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Paterson, Andrew D (author)
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Pericak-Vance, Margaret A (author)
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Schellenberg, Gerard D (author)
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Scherer, Stephen W (author)
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Sutcliffe, James S (author)
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Szatmari, Peter (author)
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Vicente, Astrid M (author)
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Vieland, Veronica J (author)
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Wijsman, Ellen M (author)
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Devlin, Bernie (author)
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Ennis, Sean (author)
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Hallmayer, Joachim (author)
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(creator_code:org_t)
- 2010-07-27
- 2010
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 19:20, s. 4072-4082
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10(-8). When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10(-8) threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alleles
- Autistic Disorder
- Genetics
- DNA Copy Number Variations
- Databases
- Genetic
- European Continental Ancestry Group
- Genetics
- Genetic Predisposition to Disease
- Genetic Variation
- Genome
- Human
- Genome-Wide Association Study
- Genotype
- Humans
- Polymorphism
- Single Nucleotide
- Risk Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Anney, Richard
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Klei, Lambertus
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Pinto, Dalila
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Regan, Regina
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Conroy, Judith
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Magalhaes, Tiago ...
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show more...
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Correia, Catarin ...
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Abrahams, Brett ...
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Sykes, Nuala
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Pagnamenta, Alis ...
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Almeida, Joana
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Bacchelli, Elena
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Bailey, Anthony ...
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Baird, Gillian
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Battaglia, Agati ...
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Berney, Tom
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Bolshakova, Nadi ...
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Bölte, Sven
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Bolton, Patrick ...
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Bourgeron, Thoma ...
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Brennan, Sean
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Brian, Jessica
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Carson, Andrew R
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Casallo, Guiller ...
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Casey, Jillian
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Chu, Su H
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Cochrane, Lynne
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Corsello, Christ ...
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Crawford, Emily ...
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Crossett, Andrew
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Dawson, Geraldin ...
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de Jonge, Mareth ...
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Delorme, Richard
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Drmic, Irene
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Duketis, Eftichi ...
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Duque, Frederico
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Estes, Annette
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Farrar, Penny
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Fernandez, Bridg ...
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Folstein, Susan ...
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Fombonne, Eric
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Freitag, Christi ...
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Gilbert, John
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Gillberg, Christ ...
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Glessner, Joseph ...
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Goldberg, Jeremy
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Green, Jonathan
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Guter, Stephen J
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Hakonarson, Hako ...
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Heron, Elizabeth ...
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Hill, Matthew
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Holt, Richard
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Howe, Jennifer L
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Hughes, Gillian
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Hus, Vanessa
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Igliozzi, Robert ...
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Kim, Cecilia
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Klauck, Sabine M
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Kolevzon, Alexan ...
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Korvatska, Olena
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Kustanovich, Vla ...
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Lajonchere, Clar ...
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Lamb, Janine A
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Laskawiec, Magda ...
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Leboyer, Marion
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Le Couteur, Ann
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Leventhal, Benne ...
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Lionel, Anath C
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Liu, Xiao-Qing
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Lord, Catherine
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Lotspeich, Linda
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Lund, Sabata C
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Maestrini, Elena
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Mahoney, William
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Mantoulan, Carin ...
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Marshall, Christ ...
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McConachie, Hele ...
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McDougle, Christ ...
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McGrath, Jane
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McMahon, William ...
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Melhem, Nadine M
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Merikangas, Alis ...
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Migita, Ohsuke
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Minshew, Nancy J
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Mirza, Ghazala K
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Munson, Jeff
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Nelson, Stanley ...
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Noakes, Carolyn
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Noor, Abdul
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Nygren, Gudrun, ...
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Oliveira, Guioma ...
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Papanikolaou, Ka ...
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Parr, Jeremy R
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Parrini, Barbara
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Paton, Tara
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Pickles, Andrew
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Piven, Joseph
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Posey, David J
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Poustka, Annemar ...
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Poustka, Fritz
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Prasad, Aparna
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Ragoussis, Jiann ...
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Renshaw, Katy
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Rickaby, Jessica
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Roberts, Wendy
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Roeder, Kathryn
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Roge, Bernadette
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Rutter, Michael ...
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Bierut, Laura J
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Rice, John P
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Salt, Jeff
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Sansom, Katherin ...
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Sato, Daisuke
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Segurado, Ricard ...
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Senman, Lili
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Shah, Naisha
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Sheffield, Val C
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Soorya, Latha
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Sousa, Inês
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Stoppioni, Vera
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Strawbridge, Chr ...
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Tancredi, Raffae ...
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Tansey, Katherin ...
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Thiruvahindrapdu ...
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Thompson, Ann P
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Thomson, Susanne
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Tryfon, Ana
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Tsiantis, John
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Van Engeland, He ...
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Vincent, John B
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Volkmar, Fred
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Wallace, Simon
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Wang, Kai
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Wang, Zhouzhi
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Wassink, Thomas ...
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Wing, Kirsty
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Wittemeyer, Kers ...
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Wood, Shawn
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Yaspan, Brian L
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Zurawiecki, Dani ...
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Zwaigenbaum, Lon ...
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Betancur, Catali ...
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Buxbaum, Joseph ...
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Cantor, Rita M
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Cook, Edwin H
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Coon, Hilary
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Cuccaro, Michael ...
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Gallagher, Louis ...
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Geschwind, Danie ...
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Gill, Michael
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Haines, Jonathan ...
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Miller, Judith
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Monaco, Anthony ...
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Nurnberger, John ...
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Paterson, Andrew ...
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Pericak-Vance, M ...
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Schellenberg, Ge ...
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Scherer, Stephen ...
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Sutcliffe, James ...
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Szatmari, Peter
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Vicente, Astrid ...
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Vieland, Veronic ...
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Wijsman, Ellen M
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Devlin, Bernie
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Ennis, Sean
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Hallmayer, Joach ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Human Molecular ...
- By the university
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University of Gothenburg