Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables

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MARC

Burgess, S. (author)

Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-03-08
Wiley,2010

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LIBRIS-ID:oai:gup.ub.gu.se/145723
https://gup.ub.gu.se/publication/145723URI
https://doi.org/10.1002/sim.3843DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191759URI
https://lup.lub.lu.se/record/1582475URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:120569369URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic markers measured in multiple studies, based on the analysis of individual participant data. First, for a single genetic marker in one study, we show that the usual ratio of coefficients approach can be reformulated as a regression with heterogeneous error in the explanatory variable. This can be implemented using a Bayesian approach, which is next extended to include multiple genetic markers. We then propose a hierarchical model for undertaking a meta-analysis of multiple studies, in which it is not necessary that the same genetic markers are measured in each study. This provides an overall estimate of the causal relationship between the phenotype and the outcome, and an assessment of its heterogeneity across studies. As an example, we estimate the causal relationship of blood concentrations of C-reactive protein on fibrinogen levels using data from 11 studies. These methods provide a flexible framework for efficient estimation of causal relationships derived from multiple studies. Issues discussed include weak instrument bias, analysis of binary outcome data such as disease risk, missing genetic data, and the use of haplotypes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
*Bayes Theorem
Biostatistics
C-Reactive Protein/genetics/metabolism
Fibrinogen/metabolism
Genetic Markers
Humans
*Meta-Analysis as Topic
Models
Statistical
Phenotype
Polymorphism
Single Nucleotide
Mendelian randomization

Added entries (persons, corporate bodies, meetings, titles ...)

Thompson, S. G. (author)
Andrews, G. (author)
Samani, N. J. (author)
Hall, A. (author)
Whincup, P. (author)
Morris, R. (author)
Lawlor, D. A. (author)
Davey Smith, G. (author)
Timpson, N. (author)
Ebrahim, S. (author)
Ben-Shlomo, Y. (author)
Brown, M. (author)
Ricketts, S. (author)
Sandhu, M. (author)
Reiner, A. (author)
Psaty, B. (author)
Lange, L. (author)
Cushman, M. (author)
Hung, J. (author)
Thompson, P. (author)
Beilby, J. (author)
Warrington, N. (author)
Palmer, L. J. (author)
Berglund, GöranLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-gbe (author)
Tybjaerg-Hansen, A. (author)
Zacho, J. (author)
Wu, C. (author)
Lowe, G. (author)
Tzoulaki, I. (author)
Kumari, M. (author)
Yamamoto, J. F. (author)
Chiodini, B. (author)
Franzosi, M. (author)
Hankey, G. J. (author)
Jamrozik, K. (author)
Palmer, L. (author)
Rimm, E. (author)
Pai, J. (author)
Heckbert, S. (author)
Bis, J. (author)
Anand, S. (author)
Engert, J. (author)
Collins, R. (author)
Clarke, R. (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Berglund, G. (author)
Ladenvall, Per,1972Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine(Swepub:gu)xladpe (author)
Johansson, L. (author)
Jansson, Jan-HåkanUmeå universitet,Medicin(Swepub:umu)jaja0006 (author)
Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001 (author)
Hingorani, A. (author)
Humphries, S. (author)
Manson, J. (author)
Watkins, H. (author)
Hopewell, J. (author)
Saleheen, D. (author)
Frossard, R. (author)
Danesh, J. (author)
Sattar, N. (author)
Robertson, M. (author)
Shepherd, J. (author)
Schaefer, E. (author)
Hofman, A. (author)
Witteman, J. C. (author)
Kardys, I. (author)
de Faire, U. (author)
Bennet, A. (author)
Ford, I. (author)
Packard, C. (author)
Casas, J. P. (author)
Smeeth, L. (author)
Wensley, F. (author)
Bowden, J. (author)
Di Angelantonio, E. (author)
Gao, P. (author)
Shah, T. (author)
Verzilli, C. (author)
Walker, M. (author)
Whittaker, J. (author)
Internmedicin - epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Statistics in medicine: Wiley29:12, s. 1298-3111097-02580277-6715

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By the author/editor: Burgess, S.; Thompson, S. G.; Andrews, G.; Samani, N. J.; Hall, A.; Whincup, P.; show more...; Morris, R.; Lawlor, D. A.; Davey Smith, G.; Timpson, N.; Ebrahim, S.; Ben-Shlomo, Y.; Brown, M.; Ricketts, S.; Sandhu, M.; Reiner, A.; Psaty, B.; Lange, L.; Cushman, M.; Hung, J.; Thompson, P.; Beilby, J.; Warrington, N.; Palmer, L. J.; Berglund, Göran; Tybjaerg-Hansen, ...; Zacho, J.; Wu, C.; Lowe, G.; Tzoulaki, I.; Kumari, M.; Yamamoto, J. F.; Chiodini, B.; Franzosi, M.; Hankey, G. J.; Jamrozik, K.; Palmer, L.; Rimm, E.; Pai, J.; Heckbert, S.; Bis, J.; Anand, S.; Engert, J.; Collins, R.; Clarke, R.; Melander, Olle; Berglund, G.; Ladenvall, Per, ...; Johansson, L.; Jansson, Jan-Håk ...; Hallmans, Göran, ...; Hingorani, A.; Humphries, S.; Manson, J.; Watkins, H.; Hopewell, J.; Saleheen, D.; Frossard, R.; Danesh, J.; Sattar, N.; Robertson, M.; Shepherd, J.; Schaefer, E.; Hofman, A.; Witteman, J. C.; Kardys, I.; de Faire, U.; Bennet, A.; Ford, I.; Packard, C.; Casas, J. P.; Smeeth, L.; Wensley, F.; Bowden, J.; Di Angelantonio, ...; Gao, P.; Shah, T.; Verzilli, C.; Walker, M.; Whittaker, J.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Other Clinical M ...

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