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Targeting neonatal ...
Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.
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Chauvier, D (author)
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Renolleau, S (author)
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Holifanjaniaina, S (author)
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Ankri, S (author)
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Bezault, M (author)
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Schwendimann, L (author)
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- Rousset, Catherine, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Casimir, R (author)
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Hoebeke, Johan (author)
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Smirnova, M (author)
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Debret, G (author)
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Trichet, A-P (author)
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- Carlsson, Ylva, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Wang, Xiaoyang, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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Bernard, E (author)
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Hébert, M (author)
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Rauzier, J-M (author)
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Matecki, S (author)
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Lacampagne, A (author)
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Rustin, P (author)
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Mariani, J (author)
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- Hagberg, Henrik, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Gressens, P (author)
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Charriaut-Marlangue, C (author)
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Jacotot, E (author)
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(creator_code:org_t)
- 2011-09-01
- 2011
- English.
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In: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 2
- Related links:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Brain protection of the newborn remains a challenging priority and represents a totally unmet medical need. Pharmacological inhibition of caspases appears as a promising strategy for neuroprotection. In a translational perspective, we have developed a pentapeptide-based group II caspase inhibitor, TRP601/ORPHA133563, which reaches the brain, and inhibits caspases activation, mitochondrial release of cytochrome c, and apoptosis in vivo. Single administration of TRP601 protects newborn rodent brain against excitotoxicity, hypoxia-ischemia, and perinatal arterial stroke with a 6-h therapeutic time window, and has no adverse effects on physiological parameters. Safety pharmacology investigations, and toxicology studies in rodent and canine neonates, suggest that TRP601 is a lead compound for further drug development to treat ischemic brain damage in human newborns.
Subject headings
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Övrig annan samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Other Social Sciences not elsewhere specified (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- caspase inhibitor; perinatal brain damage; ischemia; neuroprotection
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Chauvier, D
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Renolleau, S
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Holifanjaniaina, ...
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Ankri, S
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Bezault, M
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Schwendimann, L
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show more...
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Rousset, Catheri ...
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Casimir, R
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Hoebeke, Johan
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Smirnova, M
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Debret, G
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Trichet, A-P
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Carlsson, Ylva, ...
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Wang, Xiaoyang, ...
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Bernard, E
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Hébert, M
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Rauzier, J-M
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Matecki, S
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Lacampagne, A
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Rustin, P
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Mariani, J
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Hagberg, Henrik, ...
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Gressens, P
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Charriaut-Marlan ...
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Jacotot, E
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Other Social Sci ...
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and Other Social Sci ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Cell death & dis ...
- By the university
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University of Gothenburg