A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.

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Casey, Jillian P (author)

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.

Article/chapterEnglish2012

Publisher, publication year, extent ...

2011-10-14
Springer Science and Business Media LLC,2012

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/147587
https://gup.ub.gu.se/publication/147587URI
https://doi.org/10.1007/s00439-011-1094-6DOI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequency amongst ASD patients compared to parental controls. The analysis was performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs). We identified 25 known and 1,218 novel ASD candidate genes in the discovery analysis including CADM2, ABHD14A, CHRFAM7A, GRIK2, GRM3, EPHA3, FGF10, KCND2, PDZK1, IMMP2L and FOXP2. Furthermore, 10 of the previously reported ASD genes and 300 of the novel candidates identified in the discovery analysis were replicated in an independent sample of 1,182 trios. Our results demonstrate that regions of HH are significantly enriched for previously reported ASD candidate genes and the observed association is independent of gene size (odds ratio 2.10). Our findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
Adult
Child
Child Development Disorders
Pervasive
Genetics
Cluster Analysis
Cohort Studies
DNA Copy Number Variations
Female
Genetic Predisposition to Disease
Genetics
Genome-Wide Association Study
Methods
Genotype
Haplotypes
Genetics
Homozygote
Humans
Linkage Disequilibrium
Male
Middle Aged
Nuclear Family
Polymorphism
Single Nucleotide

Added entries (persons, corporate bodies, meetings, titles ...)

Magalhaes, Tiago (author)
Conroy, Judith M (author)
Regan, Regina (author)
Shah, Naisha (author)
Anney, Richard (author)
Shields, Denis C (author)
Abrahams, Brett S (author)
Almeida, Joana (author)
Bacchelli, Elena (author)
Bailey, Anthony J (author)
Baird, Gillian (author)
Battaglia, Agatino (author)
Berney, Tom (author)
Bolshakova, Nadia (author)
Bolton, Patrick F. (author)
Bourgeron, Thomas (author)
Brennan, Sean (author)
Cali, Phil (author)
Correia, Catarina (author)
Corsello, Christina (author)
Coutanche, Marc (author)
Dawson, Geraldine (author)
de Jonge, Maretha (author)
Delorme, Richard (author)
Duketis, Eftichia (author)
Duque, Frederico (author)
Estes, Annette (author)
Farrar, Penny (author)
Fernandez, Bridget A (author)
Folstein, Susan E (author)
Foley, Suzanne (author)
Fombonne, Eric (author)
Freitag, Christine M (author)
Gilbert, John (author)
Gillberg, Christopher,1950Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre(Swepub:gu)xgilch (author)
Glessner, Joseph T (author)
Green, Jonathan (author)
Guter, Stephen J (author)
Hakonarson, Hakon (author)
Holt, Richard (author)
Hughes, Gillian (author)
Hus, Vanessa (author)
Igliozzi, Roberta (author)
Kim, Cecilia (author)
Klauck, Sabine M (author)
Kolevzon, Alexander (author)
Lamb, Janine A (author)
Leboyer, Marion (author)
Le Couteur, Ann (author)
Leventhal, Bennett L (author)
Lord, Catherine (author)
Lund, Sabata C (author)
Maestrini, Elena (author)
Mantoulan, Carine (author)
Marshall, Christian R (author)
McConachie, Helen (author)
McDougle, Christopher J (author)
McGrath, Jane (author)
McMahon, William M (author)
Merikangas, Alison (author)
Miller, Judith (author)
Minopoli, Fiorella (author)
Mirza, Ghazala K (author)
Munson, Jeff (author)
Nelson, Stanley F (author)
Nygren, Gudrun,1957Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre(Swepub:gu)xnygrg (author)
Oliveira, Guiomar (author)
Pagnamenta, Alistair T (author)
Papanikolaou, Katerina (author)
Parr, Jeremy R (author)
Parrini, Barbara (author)
Pickles, Andrew (author)
Pinto, Dalila (author)
Piven, Joseph (author)
Posey, David J (author)
Poustka, Annemarie (author)
Poustka, Fritz (author)
Ragoussis, Jiannis (author)
Roge, Bernadette (author)
Rutter, Michael L (author)
Sequeira, Ana F (author)
Soorya, Latha (author)
Sousa, Inês (author)
Sykes, Nuala (author)
Stoppioni, Vera (author)
Tancredi, Raffaella (author)
Tauber, Maïté (author)
Thompson, Ann P (author)
Thomson, Susanne (author)
Tsiantis, John (author)
Van Engeland, Herman (author)
Vincent, John B (author)
Volkmar, Fred (author)
Vorstman, Jacob A S (author)
Wallace, Simon (author)
Wang, Kai (author)
Wassink, Thomas H (author)
White, Kathy (author)
Wing, Kirsty (author)
Wittemeyer, Kerstin (author)
Yaspan, Brian L (author)
Zwaigenbaum, Lonnie (author)
Betancur, Catalina (author)
Buxbaum, Joseph D (author)
Cantor, Rita M (author)
Cook, Edwin H (author)
Coon, Hilary (author)
Cuccaro, Michael L (author)
Geschwind, Daniel H (author)
Haines, Jonathan L (author)
Hallmayer, Joachim (author)
Monaco, Anthony P (author)
Nurnberger, John I (author)
Pericak-Vance, Margaret A (author)
Schellenberg, Gerard D (author)
Scherer, Stephen W (author)
Sutcliffe, James S (author)
Szatmari, Peter (author)
Vieland, Veronica J (author)
Wijsman, Ellen M (author)
Green, Andrew (author)
Gill, Michael (author)
Gallagher, Louise (author)
Vicente, Astrid (author)
Ennis, Sean (author)
Göteborgs universitetGillbergcentrum (creator_code:org_t)

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In:Human Genetics: Springer Science and Business Media LLC131:4, s. 565-5790340-67171432-1203

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By the author/editor: Casey, Jillian P; Magalhaes, Tiago; Conroy, Judith M; Regan, Regina; Shah, Naisha; Anney, Richard; show more...; Shields, Denis C; Abrahams, Brett ...; Almeida, Joana; Bacchelli, Elena; Bailey, Anthony ...; Baird, Gillian; Battaglia, Agati ...; Berney, Tom; Bolshakova, Nadi ...; Bolton, Patrick ...; Bourgeron, Thoma ...; Brennan, Sean; Cali, Phil; Correia, Catarin ...; Corsello, Christ ...; Coutanche, Marc; Dawson, Geraldin ...; de Jonge, Mareth ...; Delorme, Richard; Duketis, Eftichi ...; Duque, Frederico; Estes, Annette; Farrar, Penny; Fernandez, Bridg ...; Folstein, Susan ...; Foley, Suzanne; Fombonne, Eric; Freitag, Christi ...; Gilbert, John; Gillberg, Christ ...; Glessner, Joseph ...; Green, Jonathan; Guter, Stephen J; Hakonarson, Hako ...; Holt, Richard; Hughes, Gillian; Hus, Vanessa; Igliozzi, Robert ...; Kim, Cecilia; Klauck, Sabine M; Kolevzon, Alexan ...; Lamb, Janine A; Leboyer, Marion; Le Couteur, Ann; Leventhal, Benne ...; Lord, Catherine; Lund, Sabata C; Maestrini, Elena; Mantoulan, Carin ...; Marshall, Christ ...; McConachie, Hele ...; McDougle, Christ ...; McGrath, Jane; McMahon, William ...; Merikangas, Alis ...; Miller, Judith; Minopoli, Fiorel ...; Mirza, Ghazala K; Munson, Jeff; Nelson, Stanley ...; Nygren, Gudrun, ...; Oliveira, Guioma ...; Pagnamenta, Alis ...; Papanikolaou, Ka ...; Parr, Jeremy R; Parrini, Barbara; Pickles, Andrew; Pinto, Dalila; Piven, Joseph; Posey, David J; Poustka, Annemar ...; Poustka, Fritz; Ragoussis, Jiann ...; Roge, Bernadette; Rutter, Michael ...; Sequeira, Ana F; Soorya, Latha; Sousa, Inês; Sykes, Nuala; Stoppioni, Vera; Tancredi, Raffae ...; Tauber, Maïté; Thompson, Ann P; Thomson, Susanne; Tsiantis, John; Van Engeland, He ...; Vincent, John B; Volkmar, Fred; Vorstman, Jacob ...; Wallace, Simon; Wang, Kai; Wassink, Thomas ...; White, Kathy; Wing, Kirsty; Wittemeyer, Kers ...; Yaspan, Brian L; Zwaigenbaum, Lon ...; Betancur, Catali ...; Buxbaum, Joseph ...; Cantor, Rita M; Cook, Edwin H; Coon, Hilary; Cuccaro, Michael ...; Geschwind, Danie ...; Haines, Jonathan ...; Hallmayer, Joach ...; Monaco, Anthony ...; Nurnberger, John ...; Pericak-Vance, M ...; Schellenberg, Ge ...; Scherer, Stephen ...; Sutcliffe, James ...; Szatmari, Peter; Vieland, Veronic ...; Wijsman, Ellen M; Green, Andrew; Gill, Michael; Gallagher, Louis ...; Vicente, Astrid; Ennis, Sean; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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By the university: University of Gothenburg

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