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Association of psor...
Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
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Kainu, Kati (author)
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Kivinen, Katja (author)
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- Zucchelli, Marco (author)
- Karolinska Institutet
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Suomela, Sari (author)
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- Kere, Juha (author)
- Karolinska Institutet
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- Inerot, Annica, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Baker, Barbara S (author)
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Powles, Anne V (author)
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Fry, Lionel (author)
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- Samuelsson, Lena, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Saarialho-Kere, Ulpu (author)
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: Experimental dermatology. - : Wiley. - 1600-0625 .- 0906-6705. ; 18:2, s. 109-15
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- A susceptibility locus for psoriasis, PSORS4, has been mapped to chromosome 1q21 in the region of the epidermal differentiation complex. The region has been refined to a 115 kb interval around the loricrin (LOR) gene. However, no evidence of association between polymorphisms in the LOR gene and psoriasis has been found. Therefore, we have analysed association to three candidate gene clusters of the region, the S100, small proline-rich protein (SPRR) and PGLYRP (peptidoglycan recognition protein) genes, which all contain functionally interesting psoriasis candidate genes. In previous studies, the SPRR and S100 genes have shown altered expression in psoriasis. Also polymorphisms in the PGLYRP genes have shown to be associated with psoriasis. We genotyped altogether 29 single nucleotide polymorphisms (SNPs) in 255 Finnish psoriasis families and analysed association with psoriasis using transmission disequilibrium test. A five-SNP haplotype of PGLYRP SNPs associated significantly with psoriasis. There was also suggestive evidence of association to SPRR gene locus in Finnish families. To confirm the putative associations, selected SNPs were genotyped also in a family collection of Swedish and Irish patients. The families supported association to the two gene regions, but there was also evidence of allelic heterogeneity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Carrier Proteins
- genetics
- Child
- Child
- Preschool
- Chromosomes
- Human
- Pair 1
- genetics
- Cornified Envelope Proline-Rich Proteins
- genetics
- Female
- Finland
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- genetics
- Genotype
- Haplotypes
- genetics
- Humans
- Infant
- Ireland
- Male
- Middle Aged
- Polymorphism
- Single Nucleotide
- genetics
- Psoriasis
- ethnology
- genetics
- Sweden
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kainu, Kati
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Kivinen, Katja
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Zucchelli, Marco
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Suomela, Sari
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Kere, Juha
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Inerot, Annica, ...
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show more...
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Baker, Barbara S
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Powles, Anne V
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Fry, Lionel
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Samuelsson, Lena ...
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Saarialho-Kere, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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Experimental der ...
- By the university
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University of Gothenburg
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Karolinska Institutet