Search: WFRF:(Whittaker Charles A) >
Blood Pressure Loci...
Blood Pressure Loci Identified with a Gene-Centric Array.
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Johnson, Toby (author)
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Gaunt, Tom R (author)
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Newhouse, Stephen J (author)
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show more...
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Padmanabhan, Sandosh (author)
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Tomaszewski, Maciej (author)
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Kumari, Meena (author)
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Morris, Richard W (author)
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Tzoulaki, Ioanna (author)
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O'Brien, Eoin T (author)
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Poulter, Neil R (author)
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Sever, Peter (author)
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Shields, Denis C (author)
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Thom, Simon (author)
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Wannamethee, Sasiwarang G (author)
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Whincup, Peter H (author)
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Brown, Morris J (author)
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Connell, John M (author)
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Dobson, Richard J (author)
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Howard, Philip J (author)
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Mein, Charles A (author)
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Onipinla, Abiodun (author)
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Shaw-Hawkins, Sue (author)
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Zhang, Yun (author)
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Smith, George Davey (author)
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Day, Ian N M (author)
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Lawlor, Debbie A (author)
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- Goodall, Alison H (author)
- Karolinska Institutet
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Fowkes, F Gerald (author)
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Abecasis, Gonçalo R (author)
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Elliott, Paul (author)
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Gateva, Vesela (author)
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Braund, Peter S (author)
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Burton, Paul R (author)
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Nelson, Christopher P (author)
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Tobin, Martin D (author)
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van der Harst, Pim (author)
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Glorioso, Nicola (author)
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Neuvrith, Hani (author)
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Salvi, Erika (author)
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Staessen, Jan A (author)
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Stucchi, Andrea (author)
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Devos, Nabila (author)
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Jeunemaitre, Xavier (author)
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Plouin, Pierre-François (author)
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Tichet, Jean (author)
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Juhanson, Peeter (author)
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Org, Elin (author)
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Putku, Margus (author)
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Sõber, Siim (author)
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Veldre, Gudrun (author)
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Viigimaa, Margus (author)
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- Levinsson, Anna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine
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Thelle, Dag, 1942 (author)
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Hastie, Claire E (author)
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- Hedner, Thomas, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Lee, Wai K (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Wahlstrand, Björn, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Hardy, Rebecca (author)
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Wong, Andrew (author)
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Cooper, Jackie A (author)
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Palmen, Jutta (author)
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Chen, Li (author)
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Stewart, Alexandre F R (author)
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Wells, George A (author)
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Westra, Harm-Jan (author)
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Wolfs, Marcel G M (author)
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Clarke, Robert (author)
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Franzosi, Maria Grazia (author)
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Goel, Anuj (author)
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Hamsten, Anders (author)
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Lathrop, Mark (author)
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Peden, John F (author)
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Seedorf, Udo (author)
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Watkins, Hugh (author)
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Ouwehand, Willem H (author)
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Sambrook, Jennifer (author)
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Stephens, Jonathan (author)
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Casas, Juan-Pablo (author)
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Drenos, Fotios (author)
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Holmes, Michael V (author)
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Kivimaki, Mika (author)
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Shah, Sonia (author)
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Shah, Tina (author)
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Talmud, Philippa J (author)
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Whittaker, John (author)
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Wallace, Chris (author)
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Delles, Christian (author)
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Laan, Maris (author)
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Kuh, Diana (author)
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Humphries, Steve E (author)
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Cusi, Daniele (author)
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Roberts, Robert (author)
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Newton-Cheh, Christopher (author)
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Franke, Lude (author)
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Stanton, Alice V (author)
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Dominiczak, Anna F (author)
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Farrall, Martin (author)
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Hingorani, Aroon D (author)
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Samani, Nilesh J (author)
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Caulfield, Mark J (author)
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Munroe, Patricia B (author)
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Laan, Mans (author)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: American Journal of Human Genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 89:6, s. 688-700
- Related links:
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http://www.cell.com/...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56× 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56× 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johnson, Toby
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Gaunt, Tom R
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Newhouse, Stephe ...
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Padmanabhan, San ...
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Tomaszewski, Mac ...
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Kumari, Meena
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show more...
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Morris, Richard ...
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Tzoulaki, Ioanna
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O'Brien, Eoin T
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Poulter, Neil R
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Sever, Peter
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Shields, Denis C
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Thom, Simon
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Wannamethee, Sas ...
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Whincup, Peter H
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Brown, Morris J
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Connell, John M
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Dobson, Richard ...
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Howard, Philip J
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Mein, Charles A
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Onipinla, Abiodu ...
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Shaw-Hawkins, Su ...
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Zhang, Yun
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Smith, George Da ...
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Day, Ian N M
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Lawlor, Debbie A
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Goodall, Alison ...
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Fowkes, F Gerald
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Abecasis, Gonçal ...
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Elliott, Paul
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Gateva, Vesela
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Braund, Peter S
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Burton, Paul R
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Nelson, Christop ...
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Tobin, Martin D
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van der Harst, P ...
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Glorioso, Nicola
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Neuvrith, Hani
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Salvi, Erika
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Staessen, Jan A
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Stucchi, Andrea
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Devos, Nabila
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Jeunemaitre, Xav ...
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Plouin, Pierre-F ...
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Tichet, Jean
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Juhanson, Peeter
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Org, Elin
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Putku, Margus
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Sõber, Siim
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Veldre, Gudrun
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Viigimaa, Margus
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Levinsson, Anna
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Rosengren, Annik ...
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Thelle, Dag, 194 ...
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Hastie, Claire E
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Hedner, Thomas, ...
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Lee, Wai K
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Melander, Olle
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Wahlstrand, Björ ...
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Hardy, Rebecca
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Wong, Andrew
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Cooper, Jackie A
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Palmen, Jutta
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Chen, Li
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Stewart, Alexand ...
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Wells, George A
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Westra, Harm-Jan
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Wolfs, Marcel G ...
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Clarke, Robert
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Franzosi, Maria ...
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Goel, Anuj
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Hamsten, Anders
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Lathrop, Mark
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Peden, John F
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Seedorf, Udo
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Watkins, Hugh
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Ouwehand, Willem ...
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Sambrook, Jennif ...
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Stephens, Jonath ...
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Casas, Juan-Pabl ...
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Drenos, Fotios
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Holmes, Michael ...
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Kivimaki, Mika
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Shah, Sonia
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Shah, Tina
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Talmud, Philippa ...
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Whittaker, John
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Wallace, Chris
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Delles, Christia ...
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Laan, Maris
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Kuh, Diana
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Humphries, Steve ...
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Nyberg, Fredrik, ...
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Cusi, Daniele
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Roberts, Robert
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Newton-Cheh, Chr ...
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Franke, Lude
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Stanton, Alice V
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Dominiczak, Anna ...
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Farrall, Martin
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Hingorani, Aroon ...
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Samani, Nilesh J
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Caulfield, Mark ...
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Munroe, Patricia ...
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Laan, Mans
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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American Journal ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet