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Genome-wide associa...
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
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Artigas Soler, María (author)
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Loth, Daan W (author)
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Wain, Louise V (author)
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show more...
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Gharib, Sina A (author)
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Obeidat, Ma'en (author)
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Tang, Wenbo (author)
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Zhai, Guangju (author)
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Zhao, Jing Hua (author)
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Smith, Albert Vernon (author)
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Huffman, Jennifer E (author)
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Albrecht, Eva (author)
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Jackson, Catherine M (author)
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Evans, David M (author)
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Cadby, Gemma (author)
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Fornage, Myriam (author)
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Manichaikul, Ani (author)
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Lopez, Lorna M (author)
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Johnson, Toby (author)
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Aldrich, Melinda C (author)
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Aspelund, Thor (author)
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Barroso, Inês (author)
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Campbell, Harry (author)
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Cassano, Patricia A (author)
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Couper, David J (author)
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Eiriksdottir, Gudny (author)
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Franceschini, Nora (author)
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Garcia, Melissa (author)
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Gieger, Christian (author)
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Gislason, Gauti Kjartan (author)
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Grkovic, Ivica (author)
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Hammond, Christopher J (author)
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Hancock, Dana B (author)
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Harris, Tamara B (author)
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Ramasamy, Adaikalavan (author)
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Heckbert, Susan R (author)
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Heliövaara, Markku (author)
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Homuth, Georg (author)
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Hysi, Pirro G (author)
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James, Alan L (author)
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Jankovic, Stipan (author)
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Joubert, Bonnie R (author)
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Karrasch, Stefan (author)
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Klopp, Norman (author)
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Koch, Beate (author)
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Kritchevsky, Stephen B (author)
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Launer, Lenore J (author)
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Liu, Yongmei (author)
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Loehr, Laura R (author)
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Lohman, Kurt (author)
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Loos, Ruth J F (author)
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Lumley, Thomas (author)
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Al Balushi, Khalid A (author)
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Ang, Wei Q (author)
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Barr, R Graham (author)
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Beilby, John (author)
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Blakey, John D (author)
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Boban, Mladen (author)
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Boraska, Vesna (author)
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- Brisman, Jonas, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Britton, John R (author)
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Brusselle, Guy G (author)
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Cooper, Cyrus (author)
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Curjuric, Ivan (author)
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- Dahgam, Santosh (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Deary, Ian J (author)
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Ebrahim, Shah (author)
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Eijgelsheim, Mark (author)
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Francks, Clyde (author)
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Gaysina, Darya (author)
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Granell, Raquel (author)
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Gu, Xiangjun (author)
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Hankinson, John L (author)
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Hardy, Rebecca (author)
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Harris, Sarah E (author)
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Henderson, John (author)
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Henry, Amanda (author)
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Hingorani, Aroon D (author)
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Hofman, Albert (author)
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Holt, Patrick G (author)
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Hui, Jennie (author)
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Hunter, Michael L (author)
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Imboden, Medea (author)
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Jameson, Karen A (author)
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Kerr, Shona M (author)
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Kolcic, Ivana (author)
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Kronenberg, Florian (author)
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Liu, Jason Z (author)
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Marchini, Jonathan (author)
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McKeever, Tricia (author)
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Morris, Andrew D (author)
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- Olin, Anna-Carin, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Porteous, David J (author)
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Postma, Dirkje S (author)
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Rich, Stephen S (author)
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Ring, Susan M (author)
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Rivadeneira, Fernando (author)
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Rochat, Thierry (author)
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Sayer, Avan Aihie (author)
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Sayers, Ian (author)
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Sly, Peter D (author)
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Smith, George Davey (author)
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Sood, Akshay (author)
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Starr, John M (author)
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Uitterlinden, André G (author)
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Vonk, Judith M (author)
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Wannamethee, S Goya (author)
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Whincup, Peter H (author)
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Wijmenga, Cisca (author)
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Williams, O Dale (author)
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Wong, Andrew (author)
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Mangino, Massimo (author)
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Marciante, Kristin D (author)
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McArdle, Wendy L (author)
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Meibohm, Bernd (author)
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Morrison, Alanna C (author)
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North, Kari E (author)
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Omenaas, Ernst (author)
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Palmer, Lyle J (author)
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Pietiläinen, Kirsi H (author)
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Pin, Isabelle (author)
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Pola Sbreve Ek, Ozren (author)
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Pouta, Anneli (author)
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Psaty, Bruce M (author)
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Hartikainen, Anna-Liisa (author)
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Rantanen, Taina (author)
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Ripatti, Samuli (author)
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Rotter, Jerome I (author)
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Rudan, Igor (author)
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Rudnicka, Alicja R (author)
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Schulz, Holger (author)
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Shin, So-Youn (author)
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Spector, Tim D (author)
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Surakka, Ida (author)
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Vitart, Veronique (author)
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Völzke, Henry (author)
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Wareham, Nicholas J (author)
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Warrington, Nicole M (author)
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Wichmann, H-Erich (author)
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Wild, Sarah H (author)
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Wilk, Jemma B (author)
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Wjst, Matthias (author)
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Wright, Alan F (author)
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Zgaga, Lina (author)
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Zemunik, Tatijana (author)
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Pennell, Craig E (author)
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Kuh, Diana (author)
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Holloway, John W (author)
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Boezen, H Marike (author)
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Lawlor, Debbie A (author)
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Morris, Richard W (author)
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Probst-Hensch, Nicole (author)
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Kaprio, Jaakko (author)
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Wilson, James F (author)
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Hayward, Caroline (author)
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Kähönen, Mika (author)
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Heinrich, Joachim (author)
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Musk, Arthur W (author)
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Jarvis, Deborah L (author)
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Gläser, Sven (author)
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Järvelin, Marjo-Riitta (author)
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Ch Stricker, Bruno H (author)
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Elliott, Paul (author)
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O'Connor, George T (author)
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Strachan, David P (author)
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London, Stephanie J (author)
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Hall, Ian P (author)
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Gudnason, Vilmundur (author)
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International Lung Cancer Consortium, (author)
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Tobin, Martin D (author)
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GIANT Consortium, (author)
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(creator_code:org_t)
- 2011-09-25
- 2011
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1082-90
- Related links:
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https://pure.mpg.de/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Artigas Soler, M ...
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Loth, Daan W
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Wain, Louise V
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Gharib, Sina A
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Obeidat, Ma'en
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Tang, Wenbo
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show more...
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Zhai, Guangju
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Zhao, Jing Hua
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Smith, Albert Ve ...
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Huffman, Jennife ...
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Albrecht, Eva
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Jackson, Catheri ...
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Evans, David M
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Cadby, Gemma
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Fornage, Myriam
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Manichaikul, Ani
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Lopez, Lorna M
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Johnson, Toby
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Aldrich, Melinda ...
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Aspelund, Thor
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Barroso, Inês
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Campbell, Harry
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Cassano, Patrici ...
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Couper, David J
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Eiriksdottir, Gu ...
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Franceschini, No ...
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Garcia, Melissa
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Gieger, Christia ...
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Gislason, Gauti ...
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Grkovic, Ivica
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Hammond, Christo ...
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Hancock, Dana B
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Harris, Tamara B
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Ramasamy, Adaika ...
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Heckbert, Susan ...
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Heliövaara, Mark ...
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Homuth, Georg
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Hysi, Pirro G
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James, Alan L
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Jankovic, Stipan
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Joubert, Bonnie ...
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Karrasch, Stefan
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Klopp, Norman
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Koch, Beate
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Kritchevsky, Ste ...
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Launer, Lenore J
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Liu, Yongmei
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Loehr, Laura R
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Lohman, Kurt
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Loos, Ruth J F
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Lumley, Thomas
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Al Balushi, Khal ...
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Ang, Wei Q
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Barr, R Graham
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Beilby, John
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Blakey, John D
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Boban, Mladen
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Boraska, Vesna
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Brisman, Jonas, ...
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Britton, John R
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Brusselle, Guy G
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Cooper, Cyrus
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Curjuric, Ivan
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Dahgam, Santosh
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Deary, Ian J
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Ebrahim, Shah
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Eijgelsheim, Mar ...
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Francks, Clyde
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Gaysina, Darya
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Granell, Raquel
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Gu, Xiangjun
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Hankinson, John ...
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Hardy, Rebecca
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Harris, Sarah E
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Henderson, John
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Henry, Amanda
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Hingorani, Aroon ...
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Hofman, Albert
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Holt, Patrick G
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Hui, Jennie
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Hunter, Michael ...
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Imboden, Medea
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Jameson, Karen A
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Kerr, Shona M
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Kolcic, Ivana
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Kronenberg, Flor ...
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Liu, Jason Z
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Marchini, Jonath ...
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McKeever, Tricia
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Morris, Andrew D
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Olin, Anna-Carin ...
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Porteous, David ...
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Postma, Dirkje S
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Rich, Stephen S
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Ring, Susan M
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Rivadeneira, Fer ...
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Rochat, Thierry
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Sayer, Avan Aihi ...
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Sayers, Ian
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Sly, Peter D
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Smith, George Da ...
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Sood, Akshay
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Starr, John M
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Uitterlinden, An ...
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Vonk, Judith M
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Wannamethee, S G ...
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Whincup, Peter H
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Wijmenga, Cisca
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Williams, O Dale
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Wong, Andrew
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Mangino, Massimo
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Marciante, Krist ...
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McArdle, Wendy L
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Meibohm, Bernd
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Morrison, Alanna ...
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North, Kari E
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Omenaas, Ernst
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Palmer, Lyle J
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Pietiläinen, Kir ...
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Pin, Isabelle
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Pola Sbreve Ek, ...
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Pouta, Anneli
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Psaty, Bruce M
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Hartikainen, Ann ...
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Rantanen, Taina
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Ripatti, Samuli
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Rotter, Jerome I
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Rudan, Igor
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Rudnicka, Alicja ...
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Schulz, Holger
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Shin, So-Youn
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Spector, Tim D
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Surakka, Ida
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Vitart, Veroniqu ...
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Völzke, Henry
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Wareham, Nichola ...
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Warrington, Nico ...
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Wichmann, H-Eric ...
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Wild, Sarah H
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Wilk, Jemma B
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Wjst, Matthias
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Wright, Alan F
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Zgaga, Lina
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Zemunik, Tatijan ...
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Pennell, Craig E
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Nyberg, Fredrik, ...
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Kuh, Diana
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Holloway, John W
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Boezen, H Marike
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Lawlor, Debbie A
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Morris, Richard ...
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Probst-Hensch, N ...
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Kaprio, Jaakko
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Wilson, James F
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Hayward, Carolin ...
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Kähönen, Mika
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Heinrich, Joachi ...
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Musk, Arthur W
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Jarvis, Deborah ...
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Gläser, Sven
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Järvelin, Marjo- ...
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Ch Stricker, Bru ...
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Elliott, Paul
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O'Connor, George ...
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Strachan, David ...
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London, Stephani ...
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Hall, Ian P
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Gudnason, Vilmun ...
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International Lu ...
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Tobin, Martin D
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GIANT Consortium ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Nature genetics
- By the university
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University of Gothenburg