Tyck till om SwePub Sök
här!
Sökning: WFRF:(Dahlgren Johan P.)
> Karlsson Jennie 1979 >
In vivo-transmigrat...
-
Christenson, KarinGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
(författare)
In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation.
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
-
2011-06-22
-
Oxford University Press (OUP),2011
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/149810
-
https://gup.ub.gu.se/publication/149810URI
-
https://doi.org/10.1189/jlb.0111051DOI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Neutrophils respond to microbial invasion or injury by transmigration from blood to tissue. Transmigration involves cellular activation and degranulation, resulting in altered levels of surface receptors and changed responsiveness to certain stimuli. Thus, fundamental functional changes are associated with neutrophil transmigration from blood to tissue. Neutrophils isolated from peripheral blood spontaneously enter apoptosis, a process that can be accelerated or delayed by different pro- or antiapoptotic factors. How tissue neutrophils that have transmigrated in vivo regulate cell death is poorly understood. In this study, in vivo-transmigrated neutrophils (tissue neutrophils) were collected using a skin chamber technique and compared with blood neutrophils from the same donors with respect to regulation of cell death. Skin chamber fluid contained a variety of cytokines known to activate neutrophils and regulate their lifespan. Freshly prepared tissue neutrophils had elevated activity of caspase 3/7 but were fully viable; spontaneous cell death after in vitro culture was also similar between blood and tissue neutrophils. Whereas apoptosis of cultured blood neutrophils was delayed by soluble antiapoptotic factors (e.g., TLR ligands), tissue neutrophils were completely resistant to antiapoptotic stimulation, even though receptors were present and functional. In vitro transmigration of blood neutrophils into skin chamber fluid did not fully confer resistance to antiapoptotic stimulation, indicating that a block of antiapoptotic signaling occurs specifically during in vivo transmigration. We describe a novel, functional alteration that takes place during in vivo transmigration and highlights the fact that life and death of neutrophils may be regulated differently in blood and tissue.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Björkman, Lena,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xblenv
(författare)
-
Karlsson, Jennie,1979Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xkajen
(författare)
-
Sundqvist, MartinaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xsundq
(författare)
-
Movitz, Charlotta,1970Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xmovch
(författare)
-
Speert, David P
(författare)
-
Dahlgren, Claes,1949Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xdahcl
(författare)
-
Bylund, Johan,1975Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xbyljo
(författare)
-
Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of leukocyte biology: Oxford University Press (OUP)90:6, s. 1055-631938-36730741-5400
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Christenson, Kar ...
-
Björkman, Lena, ...
-
Karlsson, Jennie ...
-
Sundqvist, Marti ...
-
Movitz, Charlott ...
-
Speert, David P
-
visa fler...
-
Dahlgren, Claes, ...
-
Bylund, Johan, 1 ...
-
visa färre...
- Artiklar i publikationen
-
Journal of leuko ...
- Av lärosätet
-
Göteborgs universitet