Sökning: WFRF:(Hauptmann Michael) >
Estrogen receptor-a...
Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer.
-
- Kok, Marleen (författare)
- Netherlands Canc Inst, Dept Expt Therapy, Amsterdam, Netherlands
-
- Wigerup, Caroline (författare)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Lund Univ, Malmo Univ Hosp, Ctr Mol Pathol, Malmo, Sweden
-
- Hauptmann, Michael (författare)
- Netherlands Canc Inst, Dept Bioinformat and Stat, Amsterdam, Netherlands
-
visa fler...
-
- Michalides, Rob (författare)
- Netherlands Canc Inst, Dept Tumor Biol, Amsterdam, Netherlands
-
- Stål, Olle (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
-
- Linn, Sabine (författare)
- Netherlands Canc Inst, Dept Mol Biol, Amsterdam, Netherlands
-
- Landberg, Göran, 1963 (författare)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Univ Manchester, Breakthrough Breast Canc Res Unit, Sch Canc Enabling Sci and Technol,Christie NHS Fdn, Manchester Acad Hlth Sci Ctr,Paterson Inst Canc R, Manchester M20 4BX, Lancs, England
-
visa färre...
-
(creator_code:org_t)
- 2009-12-16
- 2009
- Engelska.
-
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 101:24, s. 1725-9
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
http://www.ncbi.nlm....
-
http://dx.doi.org/10...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Although estrogen receptor-alpha (ER) [corrected] is a marker used to identify breast cancer patients most likely to benefit from endocrine therapy, approximately 50% of ER-positive [corrected] breast carcinomas are resistant to tamoxifen. Preclinical studies have shown that phosphorylation of ER [corrected] at serine-118 (ER alpha S118-P) is required for tamoxifen-mediated inhibition of ER-induced [corrected] gene expression. We evaluated the association between recurrence-free survival after tamoxifen treatment and ER alpha S118-P expression by use of Cox proportional hazards regression. Data were from 239 premenopausal patients with breast cancer who participated in a randomized trial of 2 years of adjuvant tamoxifen treatment vs no systemic treatment. ER alpha S118-P expression was assessed by immunohistochemistry and categorized by use of the Allred score (low expression = score of 0-6; high expression = score of 7-8). All statistical tests were two-sided. Compared with systemically untreated patients, we found evidence of a benefit from adjuvant tamoxifen among patients whose tumors had high ER alpha S118-P expression (23.7 recurrences per 1000 person-years versus 72.2 recurrences per 1000 person-years, hazard ratio [HR] of recurrence = 0.36, 95% confidence interval [CI] = 0.20 to 0.65) but not among patients whose tumors had low expression (51.0 recurrences per 1000 person-years versus 57.0 recurrences per 1000 person-years, HR of recurrence = 0.87, 95% CI = 0.51 to 1.48), a statistically significant difference (P for interaction = .037). ER alpha 118-P was not associated with recurrence-free survival among untreated patients. Thus, ER alpha S118-P expression appears to be associated with response to tamoxifen. [corrected]
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Antineoplastic Agents
- Hormonal
- pharmacology
- therapeutic use
- Breast Neoplasms
- drug therapy
- metabolism
- pathology
- Disease-Free Survival
- Estrogen Receptor alpha
- drug effects
- metabolism
- Female
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Multivariate Analysis
- Odds Ratio
- Phosphorylation
- drug effects
- Premenopause
- Proportional Hazards Models
- Serine
- metabolism
- Tamoxifen
- pharmacology
- therapeutic use
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas