Diagnosis and treatment of chronic constipation--a European perspective.

Sökning: WFRF:(Tack J.) > Diagnosis and treat...

BACKGROUND: Although constipation can be a chronic and severe problem, it is largely treated empirically. Evidence for the efficacy of some of the older laxatives from well-designed trials is limited. Patients often report high levels of dissatisfaction with their treatment, which is attributed to a lack of efficacy or unpleasant side-effects. Management guidelines and recommendations are limited and are not sufficiently current to include treatments that became available more recently, such as prokinetic agents in Europe. PURPOSE: We present an overview of the pathophysiology, diagnosis, current management and available guidelines for the treatment of chronic constipation, and include recent data on the efficacy and potential clinical use of the more newly available therapeutic agents. Based on published algorithms and guidelines on the management of chronic constipation, secondary pathologies and causes are first excluded and then diet, lifestyle, and, if available, behavioral measures adopted. If these fail, bulk-forming, osmotic, and stimulant laxatives can be used. If symptoms are not satisfactorily resolved, a prokinetic agent such as prucalopride can be prescribed. Biofeedback is recommended as a treatment for chronic constipation in patients with disordered defecation. Surgery should only be considered once all other treatment options have been exhausted.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Chronic Disease
Clinical Trials as Topic
Constipation
diagnosis
drug therapy
physiopathology
Defecation
drug effects
Europe
Gastrointestinal Agents
pharmacology
therapeutic use
Gastrointestinal Transit
physiology
Guidelines as Topic
Humans
Laxatives
pharmacology
therapeutic use
Patient Satisfaction

Müller-Lissner, S (författare)
Stanghellini, V (författare)
Boeckxstaens, G (författare)
Kamm, M A (författare)
Simrén, Magnus,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Medicine, Department of Internal Medicine,University of Gothenburg Centre for person-centred care (GPCC)(Swepub:gu)xsimrm (författare)
Galmiche, J-P (författare)
Fried, M (författare)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin (creator_code:org_t)

Ingår i:Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society: Wiley23:8, s. 697-7101365-2982
Ingår i:Neurogastroenterology & Motility: Wiley23:8, s. 697-7101350-1925

Av författaren/redakt...: Tack, J; Müller-Lissner, ...; Stanghellini, V; Boeckxstaens, G; Kamm, M A; Simrén, Magnus, ...; visa fler...; Galmiche, J-P; Fried, M; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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