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Differential coexpr...
Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue.
- Article/chapterEnglish2012
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2011-03-22
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Springer Science and Business Media LLC,2012
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LIBRIS-ID:oai:gup.ub.gu.se/152492
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https://gup.ub.gu.se/publication/152492URI
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https://doi.org/10.1038/ijo.2011.22DOI
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Subject category:art swepub-publicationtype
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Objective:To use a unique obesity-discordant sib-pair study design to combine differential expression analysis, expression quantitative trait loci (eQTLs) mapping and a coexpression regulatory network approach in subcutaneous human adipose tissue to identify genes relevant to the obese state.Study design:Genome-wide transcript expression in subcutaneous human adipose tissue was measured using Affymetrix U133 Plus 2.0 microarrays (Affymetrix, Santa Clara, CA, USA), and genome-wide genotyping data was obtained using an Applied Biosystems (Applied Biosystems; Life Technologies, Carlsbad, CA, USA) SNPlex linkage panel.Subjects:A total of 154 Swedish families ascertained through an obese proband (body mass index (BMI) >30kgm(-2)) with a discordant sibling (BMI>10kgm(-2) less than proband).Results:Approximately one-third of the transcripts were differentially expressed between lean and obese siblings. The cellular adhesion molecules (CAMs) KEGG grouping contained the largest number of differentially expressed genes under cis-acting genetic control. By using a novel approach to contrast CAMs coexpression networks between lean and obese siblings, a subset of differentially regulated genes was identified, with the previously GWAS obesity-associated neuronal growth regulator 1 (NEGR1) as a central hub. Independent analysis using mouse data demonstrated that this finding of NEGR1 is conserved across species.Conclusion:Our data suggest that in addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.
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Jacobson, Peter,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjacop
(author)
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Falchi, M
(author)
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Bottolo, L
(author)
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Andersson, Johanna,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xanjoh
(author)
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Petretto, E
(author)
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Bonnefond, A
(author)
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Vaillant, E
(author)
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Lecoeur, C
(author)
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Vatin, V
(author)
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Jernås, Margareta,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjernm
(author)
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Balding, D
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Petteni, M
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Park, Y S
(author)
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Aitman, T
(author)
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Richardson, S
(author)
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Sjöström, LarsGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsjosl
(author)
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Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcarle
(author)
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Froguel, P
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
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In:International Journal of Obesity: Springer Science and Business Media LLC36:1, s. 137-1471476-54970307-0565
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Walley, A J
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Jacobson, Peter, ...
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Falchi, M
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Bottolo, L
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Andersson, Johan ...
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Petretto, E
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Bonnefond, A
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Vaillant, E
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Lecoeur, C
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Vatin, V
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Jernås, Margaret ...
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Balding, D
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Petteni, M
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Park, Y S
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Aitman, T
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Richardson, S
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Sjöström, Lars
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Carlsson, Lena M ...
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Froguel, P
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