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- Göransson, Anna,1970Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Göransson, A., Department of Biomaterial Science, Institute of Surgical Science, Göteborg University, Göteborg, Sweden, Department of Prosthetic Dentistry/Dental Material Science, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden, Department of Biomaterial Science, Department of Prosthetic Dentistry/Dental Material Science, Göteborg University, SE 405 30 Göteborg, Sweden (author)
Inflammatory response to titanium surfaces with fibrinogen and catalase coatings: an in vitro study.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Wiley,2007
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/154334
- https://gup.ub.gu.se/publication/154334URI
- https://doi.org/10.1002/jbm.a.30973DOI
- https://gup.ub.gu.se/publication/48336URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-49991URI
Supplementary language notes
- Language:English
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- SwePubSwePub
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Notes
- The aim of the present study was to evaluate the possibility to modulate the early inflammatory response in vitro by coating titanium surfaces with candidate proinflammatory (fibrinogen coated turned titanium "Fib") and antiinflammatory proteins (catalase on top of fibrinogen coated turned titanium "Cat"). Additionally, turned titanium surfaces (Ti) were used as controls. The discs were incubated with human mononuclear cells. Adhered cells were investigated with respect to number, viability, differentiation (acute marker 27E10 vs. chronic marker RM3/1), and cytokine production (TNF-alpha and IL-10), after 24 and 72 h. The results indicated that it is possible to modulate the inflammatory response with protein coatings. However, the strongest inflammatory response, indicated by increased number of adhered cells and release of pro and antiinflammatory mediators, was induced by Cat. Furthermore, the cytokine production on this surface was not sensitive to LPS stimulation. Differentiation measured as the expression of the chronic cell surface marker, dominated after 72 h for all surface modifications and Cat displayed an increased number compared to the others. A decrease in the total number of adhered cells and amounts of TNF-alpha were observed on all surfaces over time. The cell viability was, in general, high for all tested surfaces. In conclusion, the study proved it possible to influence the early inflammatory response in vitro by immobilizing protein coatings to titanium surfaces. However, the catalase surface demonstrated the strongest inflammatory response, and the possibility to selectively use the potent antiinflammatory capacity of catalase needs to be further evaluated.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
- Catalase
- pharmacology
- Cell Adhesion
- Cell Differentiation
- Cell Survival
- Cells
- Cultured
- Coated Materials
- Biocompatible
- chemistry
- pharmacology
- Cytokines
- biosynthesis
- Fibrinogen
- pharmacology
- Humans
- Inflammation
- chemically induced
- Leukocytes
- Mononuclear
- cytology
- drug effects
- Materials Testing
- Surface Properties
- Titanium
- adverse effects
- Catalase/*pharmacology
- Biocompatible/chemistry/*pharmacology
- Cytokines/biosynthesis
- Fibrinogen/*pharmacology
- Inflammation/*chemically induced
- Mononuclear/cytology/drug effects
- Titanium/*adverse effects
- Coating
- TECHNOLOGY
Added entries (persons, corporate bodies, meetings, titles ...)
- Gretzer, Christina,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Department of Biomaterial Science, Institute of Surgical Science, Göteborg University, Göteborg, Sweden (author)
- Tengvall, PenttiLinköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Tekniska högskolan,Tillämpad Fysik(Swepub:liu)pente81 (author)
- Wennerberg, Ann,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Institutionen för odontologi,Institute of Odontology,Department of Biomaterial Science, Institute of Surgical Science, Göteborg University, Göteborg, Sweden, Department of Prosthetic Dentistry/Dental Material Science, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden(Swepub:gu)xwenan (author)
- Göteborgs universitetInstitutionen för odontologi (creator_code:org_t)
Related titles
- In:Journal of biomedical materials research. Part A: Wiley80:3, s. 693-91549-32961552-4965
- In:J Biomed Mater Res A: Wiley80:3, s. 693-9
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