Adenosine A2 receptor presence and synergy with cholinergic stimulation in rabbit lacrimal gland.

• Secretion from the lacrimal gland is an important part of the well-being of the eye, and a central part in the search for treatment of dry eye syndrome. Adenosine has stimulatory effects on the lacrimal gland, and can potentiate the effect of the cholinergic agonist carbachol (Cch). The aim of the present study is to investigate the presence of the adenosine A(2) receptor subtypes A(2A) and A(2B) in the rabbit lacrimal gland, and to characterize their role in regulated acinar cell secretion.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Nyckelord

Animals

Carbachol

pharmacology

Cells

Cultured

Cholinergic Agents

pharmacology

Drug Synergism

Fluorescent Antibody Technique

Lacrimal Apparatus

drug effects

metabolism

secretion

Rabbits

Receptor

Adenosine A2A

metabolism

Receptor

Adenosine A2B

metabolism

Reverse Transcriptase Polymerase Chain Reaction

Staining and Labeling

NATURAL SCIENCES

Biomedicinsk vetenskap

Biomedicin

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)