Sökning: L773:1522 1547
> (2005-2009) >
Angiotensin II rece...
-
Casselbrant, Anna,1970Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
(författare)
Angiotensin II receptors are expressed and functional in human esophageal mucosa.
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
-
American Physiological Society,2009
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/156008
-
https://gup.ub.gu.se/publication/156008URI
-
https://doi.org/10.1152/ajpgi.00255.2009DOI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Only few studies have been devoted to the actions of the renin-angiotensin system (RAS) in the human gastrointestinal tract. The present study was undertaken to elucidate the expression and action of RAS in the human esophageal mucosa. Mucosal specimens with normal histological appearance were obtained from healthy subjects undergoing endoscopy and from patients undergoing esophagectomy due to neoplasm. Gene and protein expressions of angiotensin II (Ang II) receptor type 1 (AT(1)) and type 2 (AT(2)) and angiotensin-converting enzyme (ACE) were analyzed. In vivo functionality in healthy volunteers was reflected by assessing transmucosal potential difference (PD). Ussing chamber technique was used to analyze the different effects of Ang II on its AT(1) and AT(2) receptors. Immunoreactivity to AT(1) and AT(2) was localized to stratum superficiale and spinosum in the epithelium. ACE, AT(1), and AT(2) were found in blood vessel walls. Transmucosal PD in vivo increased following administration of the AT(1) receptor antagonist candesartan. In Ussing preparations mean basal transmural PD was -6.4 mV, epithelial current (I(ep)) 34 muA/cm(2), and epithelial resistance (R(ep)) 321 Omega.cm(2). Serosal exposure to Ang II increased PD as a result of increased I(ep), whereas R(ep) was constant. Ang II given together with the selective AT(1)-receptor antagonist losartan, or AT(2) agonist C21 given alone, resulted in a similar effect. Ang II given in presence of the AT(2)-receptor antagonist PD123319 did not influence PD, but I(ep) decreased and R(ep) increased. In conclusion, Ang II receptors and ACE are expressed in the human esophageal epithelium. The results suggest that AT(2)-receptor stimulation increases epithelial ion transport, whereas the AT(1) receptor inhibits ion transport and increases R(ep).
Ämnesord och genrebeteckningar
-
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
-
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
-
Adult
-
Angiotensin II
-
pharmacology
-
Angiotensin II Type 1 Receptor Blockers
-
pharmacology
-
Angiotensin II Type 2 Receptor Blockers
-
Angiotensin Receptor Antagonists
-
Benzimidazoles
-
pharmacology
-
Biopsy
-
Blood Vessels
-
metabolism
-
Electric Impedance
-
Electrophysiological Phenomena
-
drug effects
-
physiology
-
Epithelial Cells
-
metabolism
-
Esophagus
-
cytology
-
metabolism
-
Female
-
Gene Expression
-
genetics
-
Humans
-
Hydrochloric Acid
-
pharmacology
-
Imidazoles
-
pharmacology
-
Losartan
-
pharmacology
-
Male
-
Middle Aged
-
Mucous Membrane
-
cytology
-
drug effects
-
metabolism
-
Peptidyl-Dipeptidase A
-
genetics
-
metabolism
-
Pyridines
-
pharmacology
-
Receptor
-
Angiotensin
-
Type 1
-
genetics
-
metabolism
-
Receptor
-
Angiotensin
-
Type 2
-
agonists
-
genetics
-
metabolism
-
Receptors
-
Angiotensin
-
agonists
-
metabolism
-
Tetrazoles
-
pharmacology
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Edebo, Anders,1968Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xedean
(författare)
-
Hallersund, Peter,1975Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xhpety
(författare)
-
Spak, Emma,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xanemm
(författare)
-
Helander, Herbert F,1935Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xhelah
(författare)
-
Jönson, ClaesGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xjonsh
(författare)
-
Fändriks, Lars,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xfanla
(författare)
-
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:American journal of physiology. Gastrointestinal and liver physiology: American Physiological Society297:51522-15470193-1857
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Casselbrant, Ann ...
-
Edebo, Anders, 1 ...
-
Hallersund, Pete ...
-
Spak, Emma, 1977
-
Helander, Herber ...
-
Jönson, Claes
-
visa fler...
-
Fändriks, Lars, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kirurgi
- Artiklar i publikationen
-
American journal ...
- Av lärosätet
-
Göteborgs universitet