Impact of IL28B-related single nucleotide polymorphisms on liver histopathology in chronic hepatitis C genotype 2 and 3.

• Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome following peginterferon and ribavirin therapy among HCV genotype 1 infected patients. The present study aimed to evaluate the impact of IL28B SNP variability on liver histology in the context of a phase III treatment trial (NORDynamIC) for treatment-naïve patients with chronic HCV genotype 2 or 3 infection, where pretreatment liver biopsies were mandatory.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

Adult

Alanine Transaminase

blood

Aspartate Aminotransferases

blood

Fatty Liver

complications

genetics

virology

Female

Genetic Predisposition to Disease

Hepacivirus

genetics

Hepatitis C

Chronic

blood

complications

genetics

virology

Humans

Inflammation

complications

pathology

Interleukins

genetics

Liver

pathology

virology

Male

Middle Aged

Polymorphism

Single Nucleotide

genetics

RNA

Viral

genetics

Viral Load

genetics

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)