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Fine mapping of gen...
Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
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Kauwe, John S K (author)
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Cruchaga, Carlos (author)
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Karch, Celeste M (author)
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Sadler, Brooke (author)
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Lee, Mo (author)
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Mayo, Kevin (author)
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Latu, Wayne (author)
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Su'a, Manti (author)
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Fagan, Anne M (author)
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Holtzman, David M (author)
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Morris, John C (author)
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Goate, Alison M (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2011-02-09
- 2011
- English.
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In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 6:2
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https://journals.plo...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recent genome-wide association studies of Alzheimer's disease (AD) have identified variants in BIN1, CLU, CR1 and PICALM that show replicable association with risk for disease. We have thoroughly sampled common variation in these genes, genotyping 355 variants in over 600 individuals for whom measurements of two AD biomarkers, cerebrospinal fluid (CSF) 42 amino acid amyloid beta fragments (Aβ(42)) and tau phosphorylated at threonine 181 (ptau(181)), have been obtained. Association analyses were performed to determine whether variants in BIN1, CLU, CR1 or PICALM are associated with changes in the CSF levels of these biomarkers. Despite adequate power to detect effects as small as a 1.05 fold difference, we have failed to detect evidence for association between SNPs in these genes and CSF Aβ(42) or ptau(181) levels in our sample. Our results suggest that these variants do not affect risk via a mechanism that results in a strong additive effect on CSF levels of Aβ(42) or ptau(181).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Adaptor Proteins
- Signal Transducing
- genetics
- Aged
- Aged
- 80 and over
- Alzheimer Disease
- cerebrospinal fluid
- genetics
- Amyloid beta-Peptides
- cerebrospinal fluid
- Biological Markers
- cerebrospinal fluid
- Clusterin
- genetics
- Female
- Genetic Predisposition to Disease
- genetics
- Humans
- Male
- Middle Aged
- Monomeric Clathrin Assembly Proteins
- genetics
- Nuclear Proteins
- genetics
- Peptide Fragments
- cerebrospinal fluid
- Phosphorylation
- Polymorphism
- Single Nucleotide
- Receptors
- Complement 3b
- genetics
- Serine
- metabolism
- Tumor Suppressor Proteins
- genetics
- tau Proteins
- cerebrospinal fluid
- chemistry
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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PloS one
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To the university's database
- By the author/editor
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Kauwe, John S K
-
Cruchaga, Carlos
-
Karch, Celeste M
-
Sadler, Brooke
-
Lee, Mo
-
Mayo, Kevin
-
show more...
-
Latu, Wayne
-
Su'a, Manti
-
Fagan, Anne M
-
Holtzman, David ...
-
Morris, John C
-
Goate, Alison M
-
Blennow, Kaj, 19 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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PloS one
- By the university
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University of Gothenburg