Midlife Psychological Distress Associated With Late-Life Brain Atrophy and White Matter Lesions: A 32-Year Population Study of Women.

• Long-standing psychological distress increases the risk of dementia, especially Alzheimer's disease. The present study examines the relationship between midlife psychological distress and late-life brain atrophy and white matter lesions (WMLs), which are common findings on neuroimaging in elderly subjects. A population-based sample of 1462 women, aged 38 to 60 years, was examined in 1968, with subsequent examinations in 1974, 1980, 1992, and 2000. Computed tomography (CT) of the brain was done in 379 survivors in 2000, and of those, 344 had responded to a standardized question about psychological distress in 1968, 1974, and 1980. WMLs, cortical atrophy, and central atrophy (ventricular sizes) were measured at CT scans. Compared with women reporting no distress, those reporting frequent or constant distress at one examination or more (in 1968, 1974, and 1980) more often had moderate-to-severe WMLs (multiadjusted odds ratio = 2.39, 95% confidence interval = 1.16-4.92) and moderate-to-severe temporal lobe atrophy (multiadjusted odds ratio = 2.51, 95% confidence interval = 1.04-6.05) on brain CT in 2000. Frequent/constant distress was also associated with central brain atrophy, that is, higher bicaudate ratio, higher cella media ratio, and larger third-ventricle width. Long-standing psychological distress in midlife increases risks of cerebral atrophy and WMLs on CT in late life. More studies are needed to confirm these findings and to determine potential neurobiological mechanisms of these associations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

POSTTRAUMATIC-STRESS-DISORDER

Atrophy - epidemiology

AMYLOID-BETA

DEMENTIA

Temporal Lobe - radiography

Brain - radiographyHIPPOCAMPAL VOLUME

ALZHEIMERS-DISEASE

Brain - pathology

Mental disorders

Temporal Lobe - pathology

PSYCHIATRY

Brain Diseases - epidemiology

PREVALENCE

distress

Dementia - epidemiology

RISK-FACTORS

Brain Diseases - pathology

Womens health

PSYCHOLOGY

MULTIDISCIPLINARY

Brain

Atrophy - radiography

epidemiology

85-YEAR-OLDS

population study

Stress

Psychological - epidemiology

Psychosomatic medicine

Dementia - pathology

Emotional disorders

computed tomography

MRI

white matter lesions

temporal lobe atrophy

PSYCHOLOGY

COMPUTED-TOMOGRAPHY

Stress

Psychological - pathology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)