Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents.

Johnson, Mats,1956Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University of Gothenburg (författare)

The aim of this study was to assess baseline levels and changes in plasma fatty acid profiles in children and adolescents with ADHD, in a placebo-controlled study with Omega 3/6 supplementation, and to compare with treatment response. Seventy-five children and adolescents aged 8-18years with DSM-IV ADHD were randomized to 3months of Omega 3/6 (Equazen eye q) or placebo, followed by 3months of open phase Omega 3/6 for all. n-3, n-6, n-6/n-3 ratio, EPA and DHA in plasma were measured at baseline, 3 and 6months. Subjects with more than 25% reduction in ADHD symptoms were classified as responders. At baseline, no significant differences in mean fatty acid levels were seen across active/placebo groups or responder/non-responder groups. The 0-3month changes in all parameters were significantly greater in the active group (p<0.01). Compared to non-responders, the 6-month responders had significantly greater n-3 increase at 3months and decrease in n-6/n-3 ratio at 3 and 6months (p<0.05). Omega 3/6 supplementation had a clear impact on fatty acid composition of plasma phosphatidyl choline in active versus placebo group, and the fatty acid changes appear to be associated with treatment response. The most pronounced and long-lasting changes for treatment responders compared to non-responders were in the n-6/n-3 ratio.

Månsson, Jan-Eric,1946Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg(Swepub:gu)xmanja (författare)
Östlund, SvenGothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University of Gothenburg (författare)
Fransson, Gunnar,1945Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University of Gothenburg(Swepub:gu)xfragu (författare)
Areskoug, Björn,1943Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University of Gothenburg(Swepub:cth)areskoug (författare)
Hjalmarsson, KerstinGothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University of Gothenburg (författare)
Landgren, Magnus,1955 (författare)
Kadesjö, Björn,1945Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University of Gothenburg(Swepub:gu)xkadbj (författare)
Gillberg, Christopher,1950Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University of Gothenburg(Swepub:gu)xgilch (författare)
Göteborgs universitetGillbergcentrum (creator_code:org_t)

Ingår i:Attention Deficit and Hyperactivity Disorders: Springer Science and Business Media LLC4:4, s. 199-2041866-61161866-6647

Av författaren/redakt...: Johnson, Mats, 1 ...; Månsson, Jan-Eri ...; Östlund, Sven; Fransson, Gunnar ...; Areskoug, Björn, ...; Hjalmarsson, Ker ...; visa fler...; Landgren, Magnus ...; Kadesjö, Björn, ...; Gillberg, Christ ...; visa färre...

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