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Plasma methoxytyram...
Plasma methoxytyramine: A novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status
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Eisenhofer, G. (author)
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Lenders, J. W. M. (author)
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Siegert, G. (author)
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Bornstein, S. R. (author)
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- Friberg, Peter, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Milosevic, D. (author)
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Mannelli, M. (author)
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Linehan, W. M. (author)
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Adams, K. (author)
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Timmers, H. J. (author)
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Pacak, K. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049. ; 48:11, s. 1739-1749
- Related links:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: There are currently no reliable biomarkers for malignant pheochromocytomas and paragangliomas (PPGLs). This study examined whether measurements of catecholamines and their metabolites might offer utility for this purpose. Methods: Subjects included 365 patients with PPGLs, including 105 with metastases, and a reference population of 846 without the tumour. Eighteen catecholamine-related analytes were examined in relation to tumour location, size and mutations of succinate dehydrogenase subunit B (SDHB). Results: Receiver-operating characteristic curves indicated that plasma methoxytyramine, the O-methylated metabolite of dopamine, provided the most accurate biomarker for discriminating patients with and without metastases. Plasma methoxytyramine was 4.7-fold higher in patients with than without metastases, a difference independent of tumour burden and the associated 1.6- to 1.8-fold higher concentrations of norepinephrine and normetanephrine. Increased plasma methoxytyramine was associated with SDHB mutations and extra-adrenal disease, but was also present in patients with metastases without SDHB mutations or those with metastases secondary to adrenal tumours. High risk of malignancy associated with SDHB mutations reflected large size and extra-adrenal locations of tumours, both independent predictors of metastatic disease. A plasma methoxytyramine above 0.2 nmol/L or a tumour diameter above 5 cm indicated increased likelihood of metastatic spread, particularly when associated with an extra-adrenal location. Conclusion: Plasma methoxytyramine is a novel biomarker for metastatic PPGLs that together with SDHB mutation status, tumour size and location provide useful information to assess the likelihood of malignancy and manage affected patients. (C) 2011 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Pheochromocytoma
- Paraganglioma
- Metastases
- Methoxytyramine
- Dopamine
- Metanephrines
- malignant pheochromocytoma
- clinical-experience
- benign
- expression
- management
- excretion
- dopamine
- gene
- diagnosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eisenhofer, G.
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Lenders, J. W. M ...
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Siegert, G.
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Bornstein, S. R.
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Friberg, Peter, ...
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Milosevic, D.
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show more...
-
Mannelli, M.
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Linehan, W. M.
-
Adams, K.
-
Timmers, H. J.
-
Pacak, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
- By the university
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University of Gothenburg