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The hidden third: i...
The hidden third: improving outcome in treatment-resistant depression
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Schlaepfer, T. E. (författare)
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- Ågren, Hans, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Monteleone, P. (författare)
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visa fler...
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Gasto, C. (författare)
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Pitchot, W. (författare)
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Rouillon, F. (författare)
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Nutt, D. J. (författare)
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Kasper, S. (författare)
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visa färre...
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(creator_code:org_t)
- 2012
- 2012
- Engelska.
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Ingår i: Journal of Psychopharmacology. - 0269-8811. ; 26:5, s. 587-602
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Treatment-resistant depression (TRD) presents many challenges for both patients and physicians. This review aims to evaluate the current status of the field of TRD and reflects the main findings of a consensus meeting held in September 2009. Literature searches were also conducted using PubMed and EMBASE. Abstracts of the retrieved articles were reviewed independently by the authors for inclusion. Evaluation of the clinical evidence in TRD is complicated by the absence of a validated definition, and there is a need to move away from traditional definitions of remission based on severity of symptoms to one that includes normalisation of functioning. One potential way of improving treatment of TRD is through the use of predictive biomarkers and clinical variables. The advent of new treatments may also help by focusing on neurotransmitters other than serotonin. Strategies such as the switching of antidepressants, use of combination therapy with lithium, atypical antipsychotics and other pharmacological agents can improve outcomes, and techniques such as deep brain stimulation and vagus nerve stimulation have shown promising early results. Despite consistent advances in the pharmacotherapy of mood disorders in the last decade, high rates of TRD are still a challenging aspect of overall management.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Major depressive disorder
- outcomes
- remission
- treatment resistance
- vagus nerve-stimulation
- deep brain-stimulation
- canmat clinical
- guidelines
- star-asterisk-d
- transcranial magnetic stimulation
- serotonin reuptake inhibitors
- placebo-controlled trial
- d-aspartate
- antagonist
- of-the-art
- major depression
- vanand dp
- 1991
- psychiatric clinics of north america
- v14
- p905
- udic j
- 1990
- psychiatry research
- v31
- p287
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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