Search: (WFRF:(Shuldiner Alan R.)) srt2:(2010-2014) pers:(Rivadeneira Fernando) >
Genome-wide meta-an...
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
-
2012-04-15
-
Springer Science and Business Media LLC,2012
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/161420
-
https://gup.ub.gu.se/publication/161420URI
-
https://doi.org/10.1038/ng.2249DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54103URI
-
https://lup.lub.lu.se/record/2809520URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-176250URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Published online 15 April 2012
-
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Styrkarsdottir, Unnur
(author)
-
Evangelou, Evangelos
(author)
-
Hsu, Yi-Hsiang
(author)
-
Duncan, Emma L
(author)
-
Ntzani, Evangelia E
(author)
-
Oei, Ling
(author)
-
Albagha, Omar M E
(author)
-
Amin, Najaf
(author)
-
Kemp, John P
(author)
-
Koller, Daniel L
(author)
-
Li, Guo
(author)
-
Liu, Ching-Ti
(author)
-
Minster, Ryan L
(author)
-
Moayyeri, Alireza
(author)
-
Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xvanli
(author)
-
Willner, Dana
(author)
-
Xiao, Su-Mei
(author)
-
Yerges-Armstrong, Laura M
(author)
-
Zheng, Hou-Feng
(author)
-
Alonso, Nerea
(author)
-
Eriksson, JoelGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xerjoe
(author)
-
Kammerer, Candace M
(author)
-
Kaptoge, Stephen K
(author)
-
Leo, Paul J
(author)
-
Thorleifsson, Gudmar
(author)
-
Wilson, Scott G
(author)
-
Wilson, James F
(author)
-
Aalto, Ville
(author)
-
Alen, Markku
(author)
-
Aragaki, Aaron K
(author)
-
Aspelund, Thor
(author)
-
Center, Jacqueline R
(author)
-
Dailiana, Zoe
(author)
-
Duggan, David J
(author)
-
Garcia, Melissa
(author)
-
Garcia-Giralt, Natalia
(author)
-
Giroux, Sylvie
(author)
-
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001
(author)
-
Hocking, Lynne J
(author)
-
Husted, Lise Bjerre
(author)
-
Jameson, Karen A
(author)
-
Khusainova, Rita
(author)
-
Kim, Ghi Su
(author)
-
Kooperberg, Charles
(author)
-
Koromila, Theodora
(author)
-
Kruk, Marcin
(author)
-
Laaksonen, Marika
(author)
-
Lacroix, Andrea Z
(author)
-
Lee, Seung Hun
(author)
-
Leung, Ping C
(author)
-
Lewis, Joshua R
(author)
-
Masi, Laura
(author)
-
Mencej-Bedrac, Simona
(author)
-
Nguyen, Tuan V
(author)
-
Nogues, Xavier
(author)
-
Patel, Millan S
(author)
-
Prezelj, Janez
(author)
-
Rose, Lynda M
(author)
-
Scollen, Serena
(author)
-
Siggeirsdottir, Kristin
(author)
-
Smith, Albert V
(author)
-
Svensson, OlleUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)olsv0001
(author)
-
Trompet, Stella
(author)
-
Trummer, Olivia
(author)
-
Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xmelda
(author)
-
Woo, Jean
(author)
-
Zhu, Kun
(author)
-
Balcells, Susana
(author)
-
Brandi, Maria Luisa
(author)
-
Buckley, Brendan M
(author)
-
Cheng, Sulin
(author)
-
Christiansen, Claus
(author)
-
Cooper, Cyrus
(author)
-
Dedoussis, George
(author)
-
Ford, Ian
(author)
-
Frost, Morten
(author)
-
Goltzman, David
(author)
-
Gonzalez-Macias, Jesus
(author)
-
Kähönen, Mika
(author)
-
Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)orto-mka
(author)
-
Khusnutdinova, Elza
(author)
-
Koh, Jung-Min
(author)
-
Kollia, Panagoula
(author)
-
Langdahl, Bente Lomholt
(author)
-
Leslie, William D
(author)
-
Lips, Paul
(author)
-
Ljunggren, ÖstenUppsala universitet,Institutionen för medicinska vetenskaper,Metabola bensjukdomar(Swepub:uu)osteljun
(author)
-
Lorenc, Roman S
(author)
-
Marc, Janja
(author)
-
Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xmelda
(author)
-
Obermayer-Pietsch, Barbara
(author)
-
Olmos, José M
(author)
-
Pettersson-Kymmer, UlrikaUmeå universitet,Klinisk farmakologi(Swepub:umu)ulpe0007
(author)
-
Reid, David M
(author)
-
Riancho, José A
(author)
-
Ridker, Paul M
(author)
-
Rousseau, François
(author)
-
Slagboom, P Eline
(author)
-
Tang, Nelson L S
(author)
-
Urreizti, Roser
(author)
-
Van Hul, Wim
(author)
-
Viikari, Jorma
(author)
-
Zarrabeitia, María T
(author)
-
Aulchenko, Yurii S
(author)
-
Castano-Betancourt, Martha
(author)
-
Grundberg, Elin
(author)
-
Herrera, Lizbeth
(author)
-
Ingvarsson, Thorvaldur
(author)
-
Johannsdottir, Hrefna
(author)
-
Kwan, Tony
(author)
-
Li, Rui
(author)
-
Luben, Robert
(author)
-
Medina-Gomez, Carolina
(author)
-
Palsson, Stefan Th
(author)
-
Reppe, Sjur
(author)
-
Rotter, Jerome I
(author)
-
Sigurdsson, Gunnar
(author)
-
van Meurs, Joyce B J
(author)
-
Verlaan, Dominique
(author)
-
Williams, Frances M K
(author)
-
Wood, Andrew R
(author)
-
Zhou, Yanhua
(author)
-
Gautvik, Kaare M
(author)
-
Pastinen, Tomi
(author)
-
Raychaudhuri, Soumya
(author)
-
Cauley, Jane A
(author)
-
Chasman, Daniel I
(author)
-
Clark, Graeme R
(author)
-
Cummings, Steven R
(author)
-
Danoy, Patrick
(author)
-
Dennison, Elaine M
(author)
-
Eastell, Richard
(author)
-
Eisman, John A
(author)
-
Gudnason, Vilmundur
(author)
-
Hofman, Albert
(author)
-
Jackson, Rebecca D
(author)
-
Jones, Graeme
(author)
-
Jukema, J Wouter
(author)
-
Khaw, Kay-Tee
(author)
-
Lehtimäki, Terho
(author)
-
Liu, Yongmei
(author)
-
Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xlomat
(author)
-
McCloskey, Eugene
(author)
-
Mitchell, Braxton D
(author)
-
Nandakumar, Kannabiran
(author)
-
Nicholson, Geoffrey C
(author)
-
Oostra, Ben A
(author)
-
Peacock, Munro
(author)
-
Pols, Huibert A P
(author)
-
Prince, Richard L
(author)
-
Raitakari, Olli
(author)
-
Reid, Ian R
(author)
-
Robbins, John
(author)
-
Sambrook, Philip N
(author)
-
Sham, Pak Chung
(author)
-
Shuldiner, Alan R
(author)
-
Tylavsky, Frances A
(author)
-
van Duijn, Cornelia M
(author)
-
Wareham, Nick J
(author)
-
Cupples, L Adrienne
(author)
-
Econs, Michael J
(author)
-
Evans, David M
(author)
-
Harris, Tamara B
(author)
-
Kung, Annie Wai Chee
(author)
-
Psaty, Bruce M
(author)
-
Reeve, Jonathan
(author)
-
Spector, Timothy D
(author)
-
Streeten, Elizabeth A
(author)
-
Zillikens, M Carola
(author)
-
Thorsteinsdottir, Unnur
(author)
-
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xohlcl
(author)
-
Karasik, David
(author)
-
Richards, J Brent
(author)
-
Brown, Matthew A
(author)
-
Stefansson, Kari
(author)
-
Uitterlinden, Andre G
(author)
-
Ralston, Stuart H
(author)
-
Ioannidis, John P A
(author)
-
Kiel, Douglas P
(author)
-
Rivadeneira, Fernando
(author)
-
Göteborgs universitetCentre for Bone and Arthritis Research
(creator_code:org_t)
Related titles
-
In:Nature genetics: Springer Science and Business Media LLC44:5, s. 491-5011546-17181061-4036
Internet link
Find in a library
To the university's database
- By the author/editor
-
Estrada, Karol
-
Styrkarsdottir, ...
-
Evangelou, Evang ...
-
Hsu, Yi-Hsiang
-
Duncan, Emma L
-
Ntzani, Evangeli ...
-
show more...
-
Oei, Ling
-
Albagha, Omar M ...
-
Amin, Najaf
-
Kemp, John P
-
Koller, Daniel L
-
Li, Guo
-
Liu, Ching-Ti
-
Minster, Ryan L
-
Moayyeri, Alirez ...
-
Vandenput, Liesb ...
-
Willner, Dana
-
Xiao, Su-Mei
-
Yerges-Armstrong ...
-
Zheng, Hou-Feng
-
Alonso, Nerea
-
Eriksson, Joel
-
Kammerer, Candac ...
-
Kaptoge, Stephen ...
-
Leo, Paul J
-
Thorleifsson, Gu ...
-
Wilson, Scott G
-
Wilson, James F
-
Aalto, Ville
-
Alen, Markku
-
Aragaki, Aaron K
-
Aspelund, Thor
-
Center, Jacqueli ...
-
Dailiana, Zoe
-
Duggan, David J
-
Garcia, Melissa
-
Garcia-Giralt, N ...
-
Giroux, Sylvie
-
Hallmans, Göran
-
Hocking, Lynne J
-
Husted, Lise Bje ...
-
Jameson, Karen A
-
Khusainova, Rita
-
Kim, Ghi Su
-
Kooperberg, Char ...
-
Koromila, Theodo ...
-
Kruk, Marcin
-
Laaksonen, Marik ...
-
Lacroix, Andrea ...
-
Lee, Seung Hun
-
Leung, Ping C
-
Lewis, Joshua R
-
Masi, Laura
-
Mencej-Bedrac, S ...
-
Nguyen, Tuan V
-
Nogues, Xavier
-
Patel, Millan S
-
Prezelj, Janez
-
Rose, Lynda M
-
Scollen, Serena
-
Siggeirsdottir, ...
-
Smith, Albert V
-
Svensson, Olle
-
Trompet, Stella
-
Trummer, Olivia
-
Mellström, Dan, ...
-
Woo, Jean
-
Zhu, Kun
-
Balcells, Susana
-
Brandi, Maria Lu ...
-
Buckley, Brendan ...
-
Cheng, Sulin
-
Christiansen, Cl ...
-
Cooper, Cyrus
-
Dedoussis, Georg ...
-
Ford, Ian
-
Frost, Morten
-
Goltzman, David
-
Gonzalez-Macias, ...
-
Kähönen, Mika
-
Karlsson, Magnus
-
Khusnutdinova, E ...
-
Koh, Jung-Min
-
Kollia, Panagoul ...
-
Langdahl, Bente ...
-
Leslie, William ...
-
Lips, Paul
-
Ljunggren, Östen
-
Lorenc, Roman S
-
Marc, Janja
-
Obermayer-Pietsc ...
-
Olmos, José M
-
Pettersson-Kymme ...
-
Reid, David M
-
Riancho, José A
-
Ridker, Paul M
-
Rousseau, Franço ...
-
Slagboom, P Elin ...
-
Tang, Nelson L S
-
Urreizti, Roser
-
Van Hul, Wim
-
Viikari, Jorma
-
Zarrabeitia, Mar ...
-
Aulchenko, Yurii ...
-
Castano-Betancou ...
-
Grundberg, Elin
-
Herrera, Lizbeth
-
Ingvarsson, Thor ...
-
Johannsdottir, H ...
-
Kwan, Tony
-
Li, Rui
-
Luben, Robert
-
Medina-Gomez, Ca ...
-
Palsson, Stefan ...
-
Reppe, Sjur
-
Rotter, Jerome I
-
Sigurdsson, Gunn ...
-
van Meurs, Joyce ...
-
Verlaan, Dominiq ...
-
Williams, France ...
-
Wood, Andrew R
-
Zhou, Yanhua
-
Gautvik, Kaare M
-
Pastinen, Tomi
-
Raychaudhuri, So ...
-
Cauley, Jane A
-
Chasman, Daniel ...
-
Clark, Graeme R
-
Cummings, Steven ...
-
Danoy, Patrick
-
Dennison, Elaine ...
-
Eastell, Richard
-
Eisman, John A
-
Gudnason, Vilmun ...
-
Hofman, Albert
-
Jackson, Rebecca ...
-
Jones, Graeme
-
Jukema, J Wouter
-
Khaw, Kay-Tee
-
Lehtimäki, Terho
-
Liu, Yongmei
-
Lorentzon, Matti ...
-
McCloskey, Eugen ...
-
Mitchell, Braxto ...
-
Nandakumar, Kann ...
-
Nicholson, Geoff ...
-
Oostra, Ben A
-
Peacock, Munro
-
Pols, Huibert A ...
-
Prince, Richard ...
-
Raitakari, Olli
-
Reid, Ian R
-
Robbins, John
-
Sambrook, Philip ...
-
Sham, Pak Chung
-
Shuldiner, Alan ...
-
Tylavsky, France ...
-
van Duijn, Corne ...
-
Wareham, Nick J
-
Cupples, L Adrie ...
-
Econs, Michael J
-
Evans, David M
-
Harris, Tamara B
-
Kung, Annie Wai ...
-
Psaty, Bruce M
-
Reeve, Jonathan
-
Spector, Timothy ...
-
Streeten, Elizab ...
-
Zillikens, M Car ...
-
Thorsteinsdottir ...
-
Ohlsson, Claes, ...
-
Karasik, David
-
Richards, J Bren ...
-
Brown, Matthew A
-
Stefansson, Kari
-
Uitterlinden, An ...
-
Ralston, Stuart ...
-
Ioannidis, John ...
-
Kiel, Douglas P
-
Rivadeneira, Fer ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Orthopaedics
- Articles in the publication
-
Nature genetics
- By the university
-
University of Gothenburg
-
Umeå University
-
Lund University
-
Uppsala University