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Dietary intake of i...
Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
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Molina-Montes, E. (author)
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Wark, P. A. (author)
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Sanchez, M. J. (author)
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show more...
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Norat, T. (author)
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Jakszyn, P. (author)
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Lujan-Barroso, L. (author)
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Michaud, D. S. (author)
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Crowe, F. (author)
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Allen, N. (author)
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Khaw, K. T. (author)
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Wareham, N. (author)
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Trichopoulou, A. (author)
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Adarakis, G. (author)
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Katarachia, H. (author)
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Skeie, G. (author)
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Henningsen, M. (author)
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Broderstad, A. R. (author)
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Berrino, F. (author)
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Tumino, R. (author)
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Palli, D. (author)
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Mattiello, A. (author)
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Vineis, P. (author)
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Amiano, P. (author)
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Barricarte, A. (author)
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Huerta, J. M. (author)
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Duell, E. J. (author)
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Quiros, J. R. (author)
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- Ye, W. M. (author)
- Karolinska Institutet
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Näringsforskning,Malin Sund
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Johansen, Dorthe (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Overvad, K. (author)
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Tjonneland, A. (author)
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Roswall, N. (author)
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Li, K. R. (author)
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Grote, V. A. (author)
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Steffen, A. (author)
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Boeing, H. (author)
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Racine, A. (author)
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Boutron-Ruault, M. C. (author)
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Carbonnel, F. (author)
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Peeters, P. H. M. (author)
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Siersema, P. D. (author)
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Fedirko, V. (author)
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Jenab, M. (author)
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Riboli, E. (author)
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Bueno-De-Mesquita, B. (author)
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(creator_code:org_t)
- 2012-04-16
- 2012
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 131:7
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Abstract
Subject headings
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- Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. As diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In total, 142,203 men and 334,999 women, recruited between 1992 and 2000, were included. After an average follow-up of 11.3 years, 396 men and 469 women developed exocrine pancreatic cancer. Hazard ratios and 95% confidence intervals (CIs) were obtained using Cox regression stratified by age and center, and adjusted for energy intake, smoking status, height, weight, and self-reported diabetes status. Neither intake of magnesium, total iron nor heme-iron was associated with pancreatic cancer risk. In stratified analyses, a borderline inverse association was observed among overweight men (body mass index, =25 kg/m2) with magnesium (HRper 100 mg/day increase = 0.79, 95% CI = 0.631.01) although this was less apparent using calibrated intake. In female smokers, a higher intake of heme-iron was associated with a higher pancreatic cancer risk (HR per 1 mg/day increase = 1.38, 95% CI = 1.101.74). After calibration, this risk increased significantly to 2.5-fold (95% CI = 1.225.28). Overall, dietary magnesium, total iron and heme-iron were not associated with pancreatic cancer risk during the follow-up period. Our observation that heme-iron was associated with increased pancreatic cancer risk in female smokers warrants replication in additional study populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- diet
- magnesium
- iron
- nutrients
- pancreatic cancer
- cohort
- epidemiology
- diabetes-mellitus
- insulin-resistance
- energy-intake
- epic project
- meat
- metaanalysis
- calibration
- disease
- women
- men
- diet
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Molina-Montes, E ...
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Wark, P. A.
-
Sanchez, M. J.
-
Norat, T.
-
Jakszyn, P.
-
Lujan-Barroso, L ...
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show more...
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Michaud, D. S.
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Crowe, F.
-
Allen, N.
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Khaw, K. T.
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Wareham, N.
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Trichopoulou, A.
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Adarakis, G.
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Katarachia, H.
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Skeie, G.
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Henningsen, M.
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Broderstad, A. R ...
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Berrino, F.
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Tumino, R.
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Palli, D.
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Mattiello, A.
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Vineis, P.
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Amiano, P.
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Barricarte, A.
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Huerta, J. M.
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Duell, E. J.
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Quiros, J. R.
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Ye, W. M.
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Sund, Malin, 197 ...
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Lindkvist, Björn
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Johansen, Dorthe
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Overvad, K.
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Tjonneland, A.
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Roswall, N.
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Li, K. R.
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Grote, V. A.
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Steffen, A.
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Boeing, H.
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Racine, A.
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Boutron-Ruault, ...
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Carbonnel, F.
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Peeters, P. H. M ...
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Siersema, P. D.
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Fedirko, V.
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Jenab, M.
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Riboli, E.
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Bueno-De-Mesquit ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg
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Lund University
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Umeå University
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Karolinska Institutet