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The antibody respon...
The antibody response to pandemic H1N1 2009 influenza vaccine in adult organ transplant patients.
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Felldin, Marie (author)
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- Studahl, Marie, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Svennerholm, Bo (author)
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- Friman, Vanda, 1952 (author)
- Gothenburg University,Göteborgs universitet,Extern,Institutionen för biomedicin,Institutionen för biomedicin, avdelningen för infektionssjukdomar,External,Institute of Biomedicine,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- 2011-11-26
- 2012
- English.
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In: Transplant international : official journal of the European Society for Organ Transplantation. - : Frontiers Media SA. - 1432-2277. ; 25:2, s. 166-71
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Abstract
Subject headings
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- Limited data are available regarding antibody response and the safety of the monovalent influenza A H1N1/09 vaccine for immunocompromised patients. In this study, the humoral response to this vaccine in solid organ transplant (SOT) recipients and healthy individuals was evaluated. Eighty-two SOT recipients and 28 healthy individuals received two doses of the influenza A H1N1/09 AS03 adjuvanted vaccine containing 3.75mg of haemagglutinin at a 3- to 4-week interval. Serum samples were drawn at baseline and 3-4weeks after the first and second vaccine doses. Seroprotective titres were measured with a haemagglutination inhibition. After the first dose seroprotective titres were observed in 69% of the SOT patients and in 96% of the healthy controls (P=0.006), and increased after the second dose to 80% and 100%, respectively (P=0.003). All controls and 77% of the SOT recipients achieved a ≥4-fold titre rise after the first immunisation (P=0.005). The vaccine was well tolerated and no acute rejection was observed. Influenza A H1N1/09 vaccine elicited a protective antibody response in the majority of SOT recipients, but the response was lower when compared with controls. A second dose significantly improved vaccine immunogenicity in SOT recipients. (ClinicalTrials.gov number: NCT01254955).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Adult
- Aged
- Aged
- 80 and over
- Antibodies
- Viral
- blood
- Glomerular Filtration Rate
- Humans
- Influenza A Virus
- H1N1 Subtype
- immunology
- Influenza Vaccines
- immunology
- Influenza
- Human
- epidemiology
- Middle Aged
- Organ Transplantation
- Pandemics
- Time Factors
- Vaccination
Publication and Content Type
- ref (subject category)
- art (subject category)
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