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  • Godoy, TaniaGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Odontology,Institute of Neuroscience and Physiology, Department of Pharmacology (author)

Atypical antipsychotics - effects of amisulpride on salivary secretion and on clozapine-induced sialorrhea

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012-03-28
  • Wiley,2012

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  • LIBRIS-ID:oai:gup.ub.gu.se/165241
  • https://gup.ub.gu.se/publication/165241URI
  • https://doi.org/10.1111/j.1601-0825.2012.01926.xDOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Oral Diseases (2012) 18, 680691 Objective: Amisulpride is suggested for treatment of clozapine-induced sialorrhea. However, objective measurements of its effectiveness are lacking and, preclinically, amisulpride has no effect. We currently hypothesise that amisulpride acts by reducing the nervous- rather than the clozapine-driven salivary secretion. Material and Methods: Effects of intravenous amisulpride (as well as of clozapine and raclopride, a dopamine D2/D3 antagonist) were investigated in rats, including those subjected to chronic preganglionic parasympathetic denervation (submandibular glands) or combined postganglionic parasympathetic and sympathetic denervation (parotid glands). In duct-cannulated glands, secretion was evoked reflexly, at low and maximum flow rates, and by electrical stimulation of the parasympathetic and sympathetic innervations, and administration of autonomimetics (including substance P). Results: Unlike clozapine, amisulpride had no effect on the reflexly evoked secretion at maximum rate. With respect to reflex secretion at low rate and to the secretion evoked by muscarinic, a-adrenergic, beta-adrenergic and substance P receptors, amisulpride (in contrast to raclopride) dose dependently potentiated the responses. Amisulpride had no effect on gland blood flow. Conclusions: No support for any inhibitory influence of amisulpride was found. Conversely, amisulpride universally enhanced secretion, suggesting that amisulpride is a potential drug for dry-mouth treatment. The mechanism behind the potentiation is currently unknown.

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  • Riva, A. (author)
  • Ekström, Jörgen,1944Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xeksjo (author)
  • Göteborgs universitetInstitutionen för odontologi (creator_code:org_t)

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  • In:Oral Diseases: Wiley18:7, s. 680-6911354-523X

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Godoy, Tania
Riva, A.
Ekström, Jörgen, ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Dentistry
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Neurology
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Oral Diseases
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University of Gothenburg

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