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Revisiting concepts...
Revisiting concepts of visceral nociception in irritable bowel syndrome
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Keszthelyi, D. (författare)
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Troost, F. J. (författare)
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- Simrén, Magnus, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg Centre for person-centred care (GPCC)
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Ludidi, S. (författare)
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Kruimel, J. W. (författare)
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Conchillo, J. M. (författare)
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Masclee, A. A. (författare)
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(creator_code:org_t)
- 2012-04-13
- 2012
- Engelska.
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Ingår i: European Journal of Pain. - : Wiley. - 1090-3801. ; 16:10, s. 1444-1454
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Objective Irritable bowel syndrome (IBS) is a common disorder characterized by abdominal pain related to defecation with a change in bowel habit. Patients with IBS often exhibit increased visceral sensitivity, which can be tested clinically by rectal balloon distension procedures. This paper aims to give an overview of mechanisms involved in visceral hypersensitivity in IBS by reviewing recent literature. Databases and Data Treatment A literature search in the electronic databases Pubmed and MEDLINE was executed using the search terms visceral pain or visceral nociception or visceral hypersensitivity and irritable bowel syndrome. Both original articles and review articles were considered for data extraction. Results Recent advances in molecular neurophysiology provide knowledge to better understand the underlying mechanism in pain generation in the human gut, in particular, in IBS patients. Sensitization of peripheral nociceptive afferents, more specifically high-threshold afferents, has been proposed as one of the principle mechanism in the development of visceral hypersensitivity. On the other hand, central mechanisms also play an important role. In terms of clinical testing of visceral perception, considerable discrepancies remain, however, across different centres. Conclusion Alterations in the modulatory balance of pro- and antinociceptive central processing of noxious peripheral input may serve as in integrative hypothesis for explaining visceral hypersensitivity in IBS. Nevertheless, it remains troublesome to estimate the contribution of central and peripheral factors in visceral hypersensitivity, posing a challenge in determining effective therapeutic entities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- altered rectal perception
- abdominal-pain
- gastrointestinal motility
- therapeutic implications
- intestinal permeability
- molecular-mechanisms
- serotonin release
- immune activation
- symptom severity
- human-disease
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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