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The past, present and future of renin-angiotensin aldosterone system inhibition

Mentz, R. J. (author)
Bakris, G. L. (author)
Waeber, B. (author)
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McMurray, J. J. (author)
Gheorghiade, M. (author)
Ruilope, L. M. (author)
Maggioni, A. P. (author)
Swedberg, Karl, 1944 (author)
Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,University of Gothenburg Centre for person-centred care (GPCC),Institute of Medicine, Department of Molecular and Clinical Medicine
Pina, I. L. (author)
Fiuzat, M. (author)
O'Connor, C. M. (author)
Zannad, F. (author)
Pitt, B. (author)
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 (creator_code:org_t)
Elsevier BV, 2013
2013
English.
In: International journal of cardiology. - : Elsevier BV. - 1874-1754 .- 0167-5273. ; 167:5, s. 1677-1687
  • Research review (peer-reviewed)
Abstract Subject headings
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  • The renin-angiotensin aldosterone system (RAAS) is central to the pathogenesis of cardiovascular disease. RAAS inhibition can reduce blood pressure, prevent target organ damage in hypertension and diabetes, and improve outcomes in patients with heart failure and/or myocardial infarction. This review presents the history of RAAS inhibition including a summary of key heart failure, myocardial infarction, hypertension and atrial fibrillation trials. Recent developments in RAAS inhibition are discussed including implementation and optimization of current drug therapies. Finally, ongoing clinical trials, opportunities for future trials and issues related to the barriers and approvability of novel RAAS inhibitors are highlighted.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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