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Children and adoles...
Children and adolescents with type 1 diabetes and high HbA1c - a neurodevelopmental perspective.
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- Nylander, Charlotte, 1979- (författare)
- Uppsala universitet,Pediatrik,Centrum för klinisk forskning i Sörmland (CKFD),Barnendokrinologisk forskning/Gustafsson
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- Toivonen, Henri (författare)
- Department of Paediatrics, Skaraborg Hospital, Skövde, Sweden
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- Nasic, Salmir (författare)
- Centre for Research and Development, Skaraborg Hospital, Skövde, Sweden
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- Söderström, Ulf (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
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- Tindberg, Ylva, 1966- (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Pediatrik,Barnendokrinologisk forskning/Gustafsson
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- Fernell, Elisabeth, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,Department of Paediatrics, Skaraborg Hospital, Skövde, Sweden
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(creator_code:org_t)
- 2013-01-19
- 2013
- Engelska.
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 1651-2227 .- 0803-5253. ; 102:4, s. 410-415
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- AIM: To examine the association between neurodevelopmental problems and high HbA1c among paediatric patients with type 1 diabetes. METHODS: A population-based study was performed among patients with type 1 diabetes (5-16 years) in two Swedish counties (n=233). The Five to Fifteen (FTF) questionnaire targeted neurodevelopmental qualities. Scores above the 90(th) percentile in the various domains are considered as definitive problems and scores above the 75(th) percentile as mild. FTF-scores were compared with regard to HbA1c ≤73 mmol/mol and >73 mmol/mol (8.0%). RESULTS: The response rate was 190 (82%). Neurodevelopmental problems were not over-represented among patients in general. Memory and learning problems were associated with HbA1c >73 mmol/mol (p = 0.01). This correlation was especially seen in adolescents (12-16 years) where mild executive problems (adjOR 3.1), definite memory problems (adjOR 5.0) and definite learning problems (adjOR 5.0) were associated with HbA1c >73 mmol/mol after adjustment for gender, diabetes duration and age of onset. CONCLUSION: Our findings that high HbA1c are more common in adolescent diabetes patients with neurodevelopmental problems generate the hypothesis that these problems might precede poor metabolic control. If so, early detection of neurodevelopmental problems would allow individually tailored treatment that may improve metabolic control and prevent complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Child and adolescent
- "Five to Fifteen" questionnaire
- HbA1c
- Neurodevelopmental problems
- Type 1 Diabetes Mellitus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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