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Metastasin S100A4 i...
Metastasin S100A4 is increased in proportion to radiographic damage in patients with RA.
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- Erlandsson, Malin, 1972 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Forslind, Kristina (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Andersson, Sofia E M, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Lund, Annelie (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Bokarewa, Maria, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- 2012-01-17
- 2012
- Engelska.
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Ingår i: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 51:5, s. 932-40
- Relaterad länk:
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https://academic.oup...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To assess the potential of metastasin S100A4 as a biological marker in patients with RA. METHODS: A total of 87 unselected patients with established RA (disease duration 2-44 years) and treated with MTX and infliximab at a single rheumatology centre were included in a cross-sectional study. Radiographs of hands and feet were taken prior to infliximab treatment and at inclusion (time interval 48±27 months) and scored for the radiographic damage. S100A4 levels were analysed in relation to radiographic damage, clinical disease activity (DAS-28), inflammation (IL-6, CRP, ESR), bone and cartilage markers [MMP-3, COMP, C-telopeptide of type I collagen (CTX-I)] and proto-oncogenes [survivin, insulin-like growth factor 1 (IGF-1), Flt3 ligand]. RESULTS: High levels of S100A4 were associated with severe radiographic damage (OR=3.40, P=0.025), non-response to infliximab (OR=4.63, P=0.003), presence of antibodies to infliximab (OR=6.24, P=0.003) and high levels of Flt3 ligand (OR=2.73, P=0.04). Regression analysis showed that high S100A4 was predictive for radiographic progression during infliximab treatment [positive predictive value (PPV) 0.68, P=0.05]. Low levels of S100A4 were associated with response to infliximab (OR=2.67, P=0.049), clinical remission (OR=4.01, P=0.0047) and negative RF (OR=9.22, P=0.0047). S100A4 correlated with survivin (r=0.71, P>0.0001). CONCLUSION: S100A4 levels are increased in proportion to radiographic damage and its further progression in RA patients. High S100A4 levels were associated with a poor clinical response to infliximab and high rate of anti-infliximab antibodies. The finding of a correlation between S100A4 and survivin and Flt3 ligand suggests that these proteins may represent a new cluster of biomarkers predicting radiographic progression and poor treatment response in RA patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Adult
- Aged
- Aged
- 80 and over
- Antibodies
- Monoclonal
- therapeutic use
- Antirheumatic Agents
- therapeutic use
- Arthritis
- Rheumatoid
- blood
- drug therapy
- radiography
- Biological Markers
- blood
- Bone and Bones
- radiography
- Cross-Sectional Studies
- Disease Progression
- Female
- Foot
- radiography
- Hand
- radiography
- Humans
- Inhibitor of Apoptosis Proteins
- blood
- Male
- Membrane Proteins
- blood
- Methotrexate
- therapeutic use
- Middle Aged
- Predictive Value of Tests
- S100 Proteins
- blood
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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