Phenotypic plasticity of human articular chondrocytes.

• Progenitor cells in mesenchymal tissues are important in the maintenance of tissue homeostasis and regeneration capacity. Articular cartilage is a tissue with a very low capacity for repair. One explanation could be the lack of chondrogenic progenitor cells within the adult tissue. As a test of chondrogenic differentiation potential, we examined the ability of isolated chondrocytes to take on several phenotypic identities within the mesenchymal lineage by applying culture techniques and markers used in the study of the phenotypic plasticity of marrow-derived mesenchymal stem cells (MSCs).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Adipose Tissue

Alkaline Phosphatase

analysis

Animals

Bone and Bones

cytology

Calcium

analysis

Cartilage

Articular

cytology

Cell Differentiation

Cells

Cultured

Chondrocytes

chemistry

cytology

Chondrogenesis

DNA

analysis

Humans

Mice

Mice

SCID

Osteogenesis

Phenotype

Stem Cells

cytology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)