CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells.

• Regulatory T cells expressing CD25 have been shown to protect rodents from organ-specific autoimmune diseases. Similar CD25+ cells with a memory phenotype exerting suppressive function after polyclonal or allogeneic stimulation are also present in adult human blood. We demonstrate that adult human CD25+ cells regulate the response to myelin oligodendrocyte glycoprotein (MOG), as depletion of CD25(+) cells increases responses of PBMC and the addition of purified CD25+ cells suppresses MOG-specific proliferation and IFN-gamma production of CD4(+)CD25(-) T cells. In contrast, cord blood CD25+ cells do not inhibit responses to self antigens, and only a small subpopulation of cord CD25+ cells expresses the typical phenotype of adult regulatory T cells (CD45RA(-) and GITR(+)) enabling suppression of polyclonal responses. We conclude that activation of self-reactive T cells in normal healthy individuals is prevented by the presence of self-antigen-specific CD25+ regulatory T cells and that the majority of these cells mature after birth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences (hsv//eng)

Nyckelord

Adult

CD4-Positive T-Lymphocytes

immunology

Cells

Cultured

Fetal Blood

immunology

Glucocorticoid-Induced TNFR-Related Protein

Humans

Immunologic Memory

Lymphocyte Activation

Myelin Proteins

Myelin-Associated Glycoprotein

immunology

Myelin-Oligodendrocyte Glycoprotein

Receptors

Interleukin-2

analysis

Receptors

Nerve Growth Factor

analysis

Receptors

Tumor Necrosis Factor

analysis

T-Lymphocytes

Regulatory

physiology

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art (ämneskategori)