Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors.

• Spermatozoa leaving the testis are not able to fertilize the egg in vivo. They must undergo further maturation in the epididymis. Proteins secreted to the epididymal lumen by the epithelial cells interact with the spermatozoa and enable these maturational changes, and are responsible for proper storage conditions before ejaculation. The present study was carried out in order to characterize the expression of a novel Pate (prostate and testis expression) gene family, coding for secreted cysteine-rich proteins, in the epididymis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Amino Acid Sequence

Androgens

pharmacology

Animals

Base Sequence

Epididymis

cytology

metabolism

Gene Expression Profiling

Gene Expression Regulation

drug effects

Male

Membrane Proteins

genetics

metabolism

Mice

Mice

Inbred C57BL

Microarray Analysis

Molecular Sequence Data

Multigene Family

genetics

physiology

Organ Specificity

genetics

Phylogeny

Seminal Plasma Proteins

genetics

metabolism

Sequence Homology

Testicular Hormones

pharmacology

Testis

metabolism

physiology

Publication and Content Type

ref (subject category)

art (subject category)