Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling.

• Myofibroblastic, peritubular cells in the walls of seminiferous tubules produce low levels of the extracellular matrix (ECM) protein decorin (DCN), which has the ability to interfere with growth factor (GF) signaling. In men with impaired spermatogenesis, fibrotic remodeling of these walls and accumulation of tryptase-positive mast cells (MCs) occur.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Biopsy

methods

Calcium

metabolism

Cell Proliferation

Cell Survival

Decorin

biosynthesis

Fibrosis

pathology

Humans

Infertility

Male

metabolism

Intercellular Signaling Peptides and Proteins

metabolism

Male

Mast Cells

cytology

Phosphorylation

Signal Transduction

Spermatogenesis

Testis

metabolism

pathology

Tryptases

biosynthesis

metabolism

physiology

Publication and Content Type

ref (subject category)

art (subject category)