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  • Redecke, Lars (author)

Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser.

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2013

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/172440
  • https://gup.ub.gu.se/publication/172440URI
  • https://doi.org/10.1126/science.1229663DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-189891URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host protein degradation, is a promising target to develop new treatments against sleeping sickness, a fatal disease caused by this protozoan parasite. The structure of the mature, active form of TbCatB has so far not provided sufficient information for the design of a safe and specific drug against T. brucei. By combining two recent innovations, in vivo crystallization and serial femtosecond crystallography, we obtained the room-temperature 2.1 angstrom resolution structure of the fully glycosylated precursor complex of TbCatB. The structure reveals the mechanism of native TbCatB inhibition and demonstrates that new biomolecular information can be obtained by the "diffraction-before-destruction" approach of x-ray free-electron lasers from hundreds of thousands of individual microcrystals.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Nass, Karol (author)
  • DePonte, Daniel P (author)
  • White, Thomas A (author)
  • Rehders, Dirk (author)
  • Barty, Anton (author)
  • Stellato, Francesco (author)
  • Liang, Mengning (author)
  • Barends, Thomas R M (author)
  • Boutet, Sébastien (author)
  • Williams, Garth J (author)
  • Seibert, M MarvinLinac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.(Swepub:uu)masei255 (author)
  • Seibert, M Marvin (author)
  • Aquila, Andrew (author)
  • Arnlund, DavidGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xarnda (author)
  • Bajt, Sasa (author)
  • Barth, Torsten (author)
  • Bogan, Michael J (author)
  • Caleman, CarlGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xjlinf (author)
  • Chao, Tzu-Chiao (author)
  • Doak, R Bruce (author)
  • Fleckenstein, Holger (author)
  • Frank, Matthias (author)
  • Fromme, Raimund (author)
  • Galli, Lorenzo (author)
  • Grotjohann, Ingo (author)
  • Hunter, Mark S (author)
  • Johansson, Linda C,1983Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xjlinf (author)
  • Kassemeyer, Stephan (author)
  • Katona, Gergely,1975Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xkatge (author)
  • Kirian, Richard A (author)
  • Koopmann, Rudolf (author)
  • Kupitz, Chris (author)
  • Lomb, Lukas (author)
  • Martin, Andrew V (author)
  • Mogk, Stefan (author)
  • Neutze, Richard,1969Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xneuri (author)
  • Shoeman, Robert L (author)
  • Steinbrener, Jan (author)
  • Timneanu, NicusorUppsala universitet,Molekylär biofysik(Swepub:uu)nti19847 (author)
  • Wang, Dingjie (author)
  • Weierstall, Uwe (author)
  • Zatsepin, Nadia A (author)
  • Spence, John C H (author)
  • Fromme, Petra (author)
  • Schlichting, Ilme (author)
  • Duszenko, Michael (author)
  • Betzel, Christian (author)
  • Chapman, Henry N (author)
  • Linac Coherent Light Source, Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.Institutionen för kemi och molekylärbiologi (creator_code:org_t)

Related titles

  • In:Science (New York, N.Y.): American Association for the Advancement of Science (AAAS)339:6116, s. 227-301095-92030036-8075

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