Search: WFRF:(Hermodsson Svante 1934)
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Alleviating oxidati...
Alleviating oxidative stress in cancer immunotherapy: a role for histamine?
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- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin,Institute of Laboratory Medicine
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- Dahlgren, Claes, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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- Hansson, Markus, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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- Hermodsson, Svante, 1934 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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- Lindnér, Per, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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- Mellqvist, Ulf-Henrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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Naredi, Peter, 1955 (author)
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Medical oncology (Northwood, London, England). - 1357-0560. ; 17:4, s. 258-69
- Related links:
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Interleukin-2 is a remarkable activator of lymphocytes with anti-neoplastic properties such as T-cells or natural killer cells, but tumor regression only rarely occurs in interleukin-2-treated cancer patients. In this review, we focus on interactions between monocytes/macrophages and T-cells/natural killer-cells, and in particular the role of such interactions for the outcome of cancer immunotherapy with interleukin-2. We propose that interleukin-2 therapy should be supplemented with compounds that alleviate toxicity inflicted by monocyte/macrophage-derived reactive oxygen metabolites within and around tumors. The hypothesis is founded on data demonstrating that (i) functions of intratumoral lymphocytes in many human malignant tumors are inhibited by reactive oxygen metabolites, generated by neighboring monocytes/macrophages, (ii) interleukin-2 only weakly activates T-cells or natural killer cells in an environment of oxidative stress, and (iii) inhibitors of the formation of reactive oxygen metabolites or scavengers of reactive oxygen metabolites synergize with interleukin-2 to activate these lymphocyte subsets. We also review the preclinical background to the use of histamine dihydrochloride, an inhibitor of reactive oxygen metabolite formation in monocytes/macrophages, as a supplement to cancer immunotherapy with interleukin-2.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cell Communication
- Drug Therapy
- Combination
- Histamine
- pharmacology
- Humans
- Immunotherapy
- Interleukin-2
- adverse effects
- immunology
- pharmacology
- Killer Cells
- Natural
- physiology
- Lymphocyte Subsets
- Macrophages
- drug effects
- physiology
- Monocytes
- drug effects
- physiology
- Neoplasms
- drug therapy
- immunology
- Oxidative Stress
- Reactive Oxygen Species
- metabolism
- T-Lymphocytes
- physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hellstrand, Kris ...
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Brune, Mats, 195 ...
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Dahlgren, Claes, ...
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Hansson, Markus, ...
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Hermodsson, Svan ...
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Lindnér, Per, 19 ...
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Mellqvist, Ulf-H ...
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Naredi, Peter, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Medical oncology ...
- By the university
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University of Gothenburg