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Histamine protects ...
Histamine protects T cells and natural killer cells against oxidative stress.
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- Hansson, Markus, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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- Hermodsson, Svante, 1934 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Mellqvist, Ulf-Henrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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Naredi, Peter, 1955 (author)
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- Betten, Åsa, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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Gehlsen, K R (author)
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- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. - 1079-9907. ; 19:10, s. 1135-44
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- Oxidative stress inflicted by monocytes/macrophages (MO) is recognized as an important immunosuppressive mechanism in human neoplastic disease. We report that two types of lymphocytes of relevance for protection against malignant cells, T cells and natural killer (NK) cells, became anergic to the T cell and NK cell activator interleukin-2 (IL-2) after exposure to MO-derived reactive oxygen metabolites and subsequently acquired features characteristic of apoptosis. The MO-induced anergy and apoptosis in T cells and NK cells were reversed by histamine, an inhibitor of reactive oxygen metabolite synthesis in MO. We propose that strategies to circumvent oxidative inhibition of lymphocytes may be of benefit in immunotherapy of neoplastic disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Antigens
- CD
- blood
- Antigens
- CD95
- blood
- Antigens
- Differentiation
- T-Lymphocyte
- blood
- Apoptosis
- drug effects
- Cytoprotection
- Histamine
- pharmacology
- Humans
- Immunotherapy
- methods
- Killer Cells
- Natural
- drug effects
- Lectins
- C-Type
- Ligands
- Macrophages
- drug effects
- Monocytes
- drug effects
- Oxidative Stress
- drug effects
- Reactive Oxygen Species
- metabolism
- T-Lymphocytes
- drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hansson, Markus, ...
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Hermodsson, Svan ...
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Brune, Mats, 195 ...
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Mellqvist, Ulf-H ...
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Naredi, Peter, 1 ...
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Betten, Åsa, 196 ...
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show more...
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Gehlsen, K R
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Hellstrand, Kris ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of inter ...
- By the university
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University of Gothenburg